Non-Coding RNAs and Hereditary Hemorrhagic Telangiectasia

被引：7
作者：
Cannavicci, Anthony [1 ,2 ]
Zhang, Qiuwang [2 ]
Kutryk, Michael J. B. [1 ,2 ]
机构：
[1] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada
[2] Univ Toronto, Keenan Res Ctr Biomed Sci, Div Cardiol, St Michaels Hosp,Unity Hlth Toronto, Toronto, ON M5B 1T8, Canada
来源：
JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 10期
基金：
美国国家卫生研究院;
关键词：
non-coding RNAs; microRNAs; long non-coding RNAs; hereditary hemorrhagic telangiectasia; biomarkers; endothelial cells; angiogenesis; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL-CELLS; CIRCULATING MICRORNAS; ARTERIOVENOUS-MALFORMATIONS; SIGNALING PATHWAYS; GENE; BIOMARKERS; DIAGNOSIS; CANCER; GROWTH;
D O I：
10.3390/jcm9103333
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Non-coding RNAs (ncRNAs) are functional ribonucleic acid (RNA) species that include microRNAs (miRs), a class of short non-coding RNAs (similar to 21-25 nucleotides), and long non-coding RNAs (lncRNAs) consisting of more than 200 nucleotides. They regulate gene expression post-transcriptionally and are involved in a wide range of pathophysiological processes. Hereditary hemorrhagic telangiectasia (HHT) is a rare disorder inherited in an autosomal dominant fashion characterized by vascular dysplasia. Patients can develop life-threatening vascular malformations and experience severe hemorrhaging. Effective pharmacological therapies are limited. The study of ncRNAs in HHT is an emerging field with great promise. This review will explore the current literature on the involvement of ncRNAs in HHT as diagnostic and pathogenic factors.
引用
收藏
页码：1 / 14
页数：14
相关论文
共 111 条
[1]   Mutation affecting the proximal promoter of Endoglin as the origin of hereditary hemorrhagic telangiectasia type 1 [J].
Albinana, Virginia ;
Zafra, Ma Paz ;
Colau, Jorge ;
Zarrabeitia, Roberto ;
Recio-Poveda, Lucia ;
Olavarrieta, Leticia ;
Perez-Perez, Julian ;
Botella, Luisa M. .
BMC MEDICAL GENETICS, 2017, 18
[2]  
Ardekani Ali M., 2010, Avicenna Journal of Medical Biotechnology, V2, P161
[3]   Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].
Arroyo, Jason D. ;
Chevillet, John R. ;
Kroh, Evan M. ;
Ruf, Ingrid K. ;
Pritchard, Colin C. ;
Gibson, Donald F. ;
Mitchell, Patrick S. ;
Bennett, Christopher F. ;
Pogosova-Agadjanyan, Era L. ;
Stirewalt, Derek L. ;
Tait, Jonathan F. ;
Tewari, Muneesh .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008
[4]   MiRNA-210: A Current Overview [J].
Bavelloni, Alberto ;
Ramazzotti, Giulia ;
Poli, Alessandro ;
Piazzi, Manuela ;
Focaccia, Enrico ;
Blalock, William ;
Faenza, Irene .
ANTICANCER RESEARCH, 2017, 37 (12) :6511-6521
[5]   Hereditary hemorrhagic telangiectasia: An overview of diagnosis and management in the molecular era for clinicians [J].
Bayrak-Toydemir, P ;
Mao, R ;
Lewin, S ;
McDonald, J .
GENETICS IN MEDICINE, 2004, 6 (04) :175-191
[6]   A fourth locus for hereditary hemorrhagic telangiectasia maps to chromosome 7 [J].
Bayrak-Toydemir, Pinar ;
McDonald, Jamie ;
Alkarsu, Nurten ;
Toydemir, Reha M. ;
Calderon, Fernanda ;
Tuncali, Timur ;
Tang, Wei ;
Miller, Franklin ;
Mao, Rong .
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2006, 140A (20) :2155-2162
[7]   Involvement of the TGF-β superfamily signalling pathway in hereditary haemorrhagic telangiectasia [J].
Bernabeu, Carmelo ;
Javier Blanco, Francisco ;
Langa, Carmen ;
Maria Garrido-Martin, Eva ;
Maria Botella, Luisa .
JOURNAL OF APPLIED BIOMEDICINE, 2010, 8 (03) :169-177
[8]   MicroRNA functions [J].
Bushati, Natascha ;
Cohen, Stephen M. .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2007, 23 :175-205
[9]   Crosstalk between TGF-β signaling and the microRNA machinery [J].
Butz, Henriett ;
Racz, Karoly ;
Hunyady, Laszlo ;
Patocs, Attila .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2012, 33 (07) :382-393
[10]   Decreased levels of miR-28-5p and miR-361-3p and increased levels of insulin-like growth factor 1 mRNA in mononuclear cells from patients with hereditary hemorrhagic telangiectasia [J].
Cannavicci, Anthony ;
Zhang, Qiuwang ;
Dai, Si-Cheng ;
Faughnan, Marie E. ;
Kutryk, Michael J. B. .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2019, 97 (06) :562-569
12345678910