Quantitative trait loci for refractoriness of Anopheles gambiae to Plasmodium cynomolgi B

被引：159
|
作者：
Zheng, LB
Cornel, AJ
Wang, R
Erfle, H
Voss, H
Ansorge, W
Kafatos, FC
Collins, FH
机构：
[1] EUROPEAN MOL BIOL LAB,D-69117 HEIDELBERG,GERMANY
[2] CTR DIS CONTROL & PREVENT,CHAMBLEE,GA 30341
来源：
SCIENCE | 1997年 / 276卷 / 5311期
关键词：
D O I：
10.1126/science.276.5311.425
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The severity of the malaria pandemic in the tropics is aggravated by the ongoing spread of parasite resistance to antimalarial drugs and mosquito resistance to insecticides. A strain of Anopheles gambiae, normally a major vector for human malaria in Africa, can encapsulate and kill the malaria parasites within a melanin-rich capsule in the mosquito midgut. Genetic mapping revealed one major and two minor quantitative trait loci (QTLs) for this encapsulation reaction. Understanding such antiparasite mechanisms in mosquitoes may lead to new strategies for malaria control.
引用
收藏
页码：425 / 428
页数：4
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