Mucin Expression in Gastric Cancer Reappraisal of Its Clinicopathologic and Prognostic Significance

被引：51

作者：

Kim, Dae Hwan ^{[1
]}

Shin, Nari ^{[2
]}

Kim, Gwang Ha ^{[3
]}

Song, Geum Am ^{[3
]}

Jeon, Tae-Yong ^{[1
]}

Kim, Dong-Heon ^{[1
]}

Lauwers, Gregory Y. ^{[5
,6
]}

Park, Do Youn ^{[2
,4
]}

机构：

[1] Pusan Natl Univ Hosp, Dept Surg, Pusan 602739, South Korea

[2] Pusan Natl Univ Hosp, Dept Pathol, Pusan 602739, South Korea

[3] Pusan Natl Univ Hosp, Dept Internal Med, Pusan 602739, South Korea

[4] Pusan Natl Univ, Sch Med, Pusan 602739, South Korea

[5] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[6] Harvard Univ, Sch Med, Boston, MA USA

来源：

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | 2013年 / 137卷 / 08期

关键词：

RING CELL CARCINOMAS; PHENOTYPE; MUC5AC; ADENOCARCINOMA; HISTOGENESIS;

D O I：

10.5858/arpa.2012-0193-OA

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Context.-The clinical validity of mucin expression in gastric cancer is debated. Whereas several reports demonstrate a correlation between mucin expression and prognosis, others deny such an association. Objective.-This survival analysis study aims to elucidate the prognostic significance of mucin expression in gastric cancer. Design.-A retrospective survival analysis was done with 412 cases of gastric cancer characterized on the basis of MUC immunohistochemistry using MUC2, MUC5AC, MUC6, and CD10 antibodies; the cases were divided into those with a gastric, an intestinal, or a null mucin phenotype based on the predominant mucin. Results.-There was no association between mucin expression and survival when considering overall gastric cancers or the advanced gastric cancer subtype. However, early gastric cancers with a gastric mucin phenotype showed longer survival than those with an intestinal mucin phenotype (P = .01) or a null phenotype (P = .01). In particular, MUC5AC-positive early gastric cancers resulted in longer survival than did those that did not express MUC5AC (P = .009). The loss of MUC5AC expression was identified as an independent, poor prognostic factor in early gastric cancers using the Cox regression proportional hazard model (hazard ratio, 3.50; P = .045). Conclusions.-MUC5AC expression is significantly associated with patient survival and can be used to predict outcomes in the gastric cancers, especially in the early gastric cancers.

引用

页码：1047 / 1053

页数：7

共 26 条

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