Iridal-Type Triterpenoids with Neuroprotective Activities from Iris tectorum

被引：41

作者：

Zhang, Chun-Lei ^{[1
,2
]}

Wang, Yan ^{[1
,2
]}

Liu, Yan-Fei ^{[1
,2
]}

Ni, Gang ^{[1
,2
]}

Liang, Dong ^{[1
,2
]}

Luo, Huan ^{[1
,2
]}

Song, Xiu-Yun ^{[1
,2
]}

Zhang, Wan-Qing ^{[1
,2
]}

Chen, Ruo-Yun ^{[1
,2
]}

Chen, Nai-Hong ^{[1
,2
]}

Yu, De-Quan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 02期

关键词：

BELAMCANDA-CHINENSIS; CELL LINES;

D O I：

10.1021/np400937f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six novel iridal-type triterpenoids with a previously unreported 3,6-dihydro-2H-pyran moiety, named spirioiridotectals A-F (1-6), were isolated from the ethanol extract of the rhizomes of Iris tectorum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Furthermore, in in vitro bioactivity assays? compounds 1, 2, and 6 exhibited neuroprotective activities against serum-deprivation-induced PC12 cell damage.

引用

收藏

页码：411 / 415

页数：5

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