The role of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: a chemical perspective

被引：0
作者：
Cole, C [1 ]
Foster, AJ [1 ]
Freeman, S [1 ]
Jaffar, M [1 ]
Murray, PE [1 ]
Stratford, IJ [1 ]
机构：
[1] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England
来源：
ANTI-CANCER DRUG DESIGN | 1999年 / 14卷 / 05期
关键词：
angiogenesis; anti-cancer drugs; 5-fluorouracil; PD-ECGF; thymidine phosphorylase; TP inhibitors;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The angiogenic growth factor thymidine phosphorylase/PD-ECGF has been identified as a potential target in the development of anti-cancer drugs. This review firstly discusses the biological role of TP/PD-ECGF and its importance in the activation of 5-fluorouracil and its prodrugs. The chemistry and chemotherapeutic potential of TP/PD-ECGF inhibitors are also discussed.
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页码：383 / 392
页数：10
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