Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

被引：313

作者：

de la Fuente, Jose ^{[1
,2
]}

Antunes, Sandra ^{[3
]}

Bonnet, Sarah ^{[4
]}

Cabezas-Cruz, Alejandro ^{[4
,5
,6
]}

Domingos, Ana G. ^{[3
]}

Estrada-Pena, Agustin ^{[7
]}

Johnson, Nicholas ^{[8
,9
]}

Kocan, Katherine M. ^{[2
]}

Mansfield, Karen L. ^{[8
,10
]}

Nijhof, Ard M. ^{[11
]}

Papa, Anna ^{[12
]}

Rudenko, Nataliia ^{[5
]}

Villar, Margarita ^{[1
]}

Alberdi, Pilar ^{[1
]}

Torina, Alessandra ^{[13
]}

Ayllon, Nieves ^{[1
]}

Vancova, Marie ^{[5
]}

Golovchenko, Maryna ^{[5
]}

Grubhoffer, Libor ^{[5
,6
]}

Caracappa, Santo ^{[13
]}

Fooks, Anthony R. ^{[8
,10
]}

Gortazar, Christian ^{[1
]}

Rego, Ryan O. M. ^{[5
,6
]}

机构：

[1] UCLM, CSIC, JCCM, Inst Invest Recursos Cineget,SaBio, Ciudad Real, Spain

[2] Oklahoma State Univ, Ctr Vet Hlth Sci, Dept Vet Pathobiol, Stillwater, OK 74078 USA

[3] Univ Nova Lisboa, Inst Higiene Med Trop, Global Hlth & Trop Med, Lisbon, Portugal

[4] UMR BIPAR INRA, ANSES, ENVA, Maisons Alfort, France

[5] Czech Acad Sci, Biol Ctr, Inst Parasitol, Ceske Budejovice, Czech Republic

[6] Univ South Bohemia, Fac Sci, Ceske Budejovice, Czech Republic

[7] Univ Zaragoza, Fac Vet, Zaragoza, Spain

[8] Anim & Plant Hlth Agcy, Surrey, England

[9] Univ Surrey, Fac Hlth & Med, Guildford, Surrey, England

[10] Univ Liverpool, Inst Infect & Global Hlth, Liverpool, Merseyside, England

[11] Free Univ Berlin, Inst Parasitol & Trop Vet Med, Berlin, Germany

[12] Aristotle Univ Thessaloniki, Med Sch, Dept Microbiol, Thessaloniki, Greece

[13] Intituto Zooprofilatt Sperimentale Sicilia, Natl Ctr Reference Anaplasma Babesia Rickettsia &, Sicily, Italy

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2017年 / 7卷

关键词：

tick; Anaplasma; flavivirus; Babesia; Borrelia; Microbiome; immunology; vaccine; CANDIDATUS-MIDICHLORIA-MITOCHONDRII; HEMORRHAGIC-FEVER VIRUS; LONE STAR TICK; ANAPLASMA-PHAGOCYTOPHILUM INFECTION; RHIPICEPHALUS BOOPHILUS MICROPLUS; MOUNTAIN WOOD TICK; IXODES-SCAPULARIS; LYME-DISEASE; BORRELIA-BURGDORFERI; DIFFERENTIAL EXPRESSION;

D O I：

10.3389/fcimb.2017.00114

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.

引用

页数：13

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