Preparation of bisthiourea and 5-Amino-4-benzoyl-1,2,4-triazol-3-thione complexes of Copper (II), Nickel and Zinc and their biological evolution

Novel Cu(II), Ni(II) and Zn(II) complexes that have N-({2-[(allylamino)carbonothioyl] hydrazino} carbonothioyl) benzamide, 5-allylamino-4-benzoyl-2,4-dihydro-3H-1,2,4-triazole-3-thione and 3-benzoyl-6-bromo- 3,5,6,7-tetrahydro[1,2,4]triazolo[1,5-a]pyrimidine-2(1H)-thione moieties have been synthesized. All complexes were prepared by the same technique by means of the interaction of ligands and a corresponding metal (molar ratio 3: 1) in boiling water-ethanol solution during 5 min. All the new compounds have been characterized by elemental analysis and various spectroscopic methods (IR, UV, H-1, C-13 NMR), and particularly for Ni(L-1)(2) by X-ray crystal structure determination. In addition, the possibility of biological evolution of the obtained compounds is shown. (C) 2015 Elsevier B.V. All rights reserved.