One-step three-component coupling of aromatic organozinc reagents, secondary amines, and aromatic aldehydes into functionalized diarylmethylamines

被引：28
|
作者：
Le Gall, Erwan [1 ]
Troupel, Michel [1 ]
Nedelec, Jean-Yves [1 ]
机构：
[1] Univ Paris 12, LECSO, CNRS, UMR 7582, F-94320 Thiais, France
来源：
TETRAHEDRON | 2006年 / 62卷 / 42期
关键词：
diarylmethylamines; multi-component reaction; aromatic organozinc reagents; aromatic aldehydes; secondary amines;
D O I：
10.1016/j.tet.2006.08.008
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Numerous functionalized diarylmethylamines have been synthesized in high yield according to a one-step three-component coupling between an aromatic organozine reagent, a secondary amine, and an aromatic aldehyde. Both organozinc species and aldehyde can bear a functional group and either aromatic or non-aromatic amines can be used in this versatile procedure. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9953 / 9965
页数：13
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