Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP)

被引：56

作者：

Lamichhane, Santosh ^{[1
,2
]}

Ahonen, Linda ^{[3
]}

Dyrlund, Thomas Sparholt ^{[3
]}

Kemppainen, Esko ^{[1
,2
]}

Siljander, Heli ^{[4
,5
,6
]}

Hyoty, Heikki ^{[7
,8
]}

Ilonen, Jorma ^{[9
,10
]}

Toppari, Jorma ^{[11
,12
]}

Veijola, Riitta ^{[13
,14
,15
]}

Hyotylainen, Tuulia ^{[16
]}

Knip, Mikael ^{[4
,5
,6
,17
,18
]}

Oresic, Matej ^{[1
,2
,19
]}

机构：

[1] Univ Turku, Turku Ctr Biotechnol, FIN-20520 Turku, Finland

[2] Abo Akad Univ, Turku 20520, Finland

[3] Steno Diabet Ctr Copenhagen, DK-2820 Gentofte, Denmark

[4] Univ Helsinki, Childrens Hosp, Helsinki 00290, Finland

[5] Helsinki Univ Hosp, Helsinki 00290, Finland

[6] Univ Helsinki, Res Program Unit, Diabet & Obes, FIN-00290 Helsinki, Finland

[7] Univ Tampere, Fac Med & Life Sci, Tampere, Finland

[8] Pirkanmaa Hosp Dist, Fimlab Labs, Tampere, Finland

[9] Univ Turku, Inst Biomed, Immunogenet Lab, Turku, Finland

[10] Turku Univ Hosp, Clin Microbiol, Turku, Finland

[11] Univ Turku, Ctr Integrat Physiol & Pharmacol, Inst Biomed, Turku, Finland

[12] Turku Univ Hosp, Dept Pediat, Turku, Finland

[13] Univ Oulu, Med Res Ctr, PEDEGO Res Unit, Dept Paediat, Oulu, Finland

[14] Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland

[15] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden

[16] Orebro Univ, Dept Chem, S-70281 Orebro, Sweden

[17] Tampere Univ Hosp, Tampere Ctr Child Hlth Res, Tampere, Finland

[18] Folkhalsan Res Ctr, Helsinki, Finland

[19] Orebro Univ, Sch Med Sci, S-70281 Orebro, Sweden

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

基金：

芬兰科学院;

关键词：

AMINO-ACID; RISK; CHOLESTEROL; METABOLISM; DISCOVERY; CHILDREN; PATTERNS; HLA-DQB1;

D O I：

10.1038/s41598-018-28907-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 plasma samples from 40 children who progressed to T1D (PT1D), 40 children who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab) and 40 matched controls (CTR). Sphingomyelins were found to be persistently downregulated in PT1D when compared to the P1Ab and CTR groups. Triacylglycerols and phosphatidylcholines were mainly downregulated in PT1D as compared to P1Ab at the age of 3 months. Our study suggests that distinct lipidomic signatures characterize children who progressed to islet autoimmunity or overt T1D, which may be helpful in the identification of at-risk children before the initiation of autoimmunity.

引用

页数：12

共 51 条

[51] Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children [J].

Ziegler, Anette G. ;

Rewers, Marian ;

Simell, Olli ;

Simell, Tuula ;

Lempainen, Johanna ;

Steck, Andrea ;

Winkler, Christiane ;

Ilonen, Jorma ;

Veijola, Riitta ;

Knip, Mikael ;

Bonifacio, Ezio ;

Eisenbarth, George S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (23) :2473-2479

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