From public health genomics to precision public health: a 20-year journey

被引：115

作者：

Khoury, Muin J. ^{[1
]}

Bowen, M. Scott ^{[1
]}

Clyne, Mindy ^{[2
]}

Dotson, W. David ^{[1
]}

Gwinn, Marta L. ^{[3
]}

Green, Ridgely Fisk ^{[1
]}

Kolor, Katherine ^{[1
]}

Rodriguez, Juan L. ^{[4
]}

Wulf, Anja ^{[1
]}

Yu, Wei ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Off Publ Hlth Gen, Atlanta, GA USA

[2] NCI, Div Canc Control & Populat Sci, Rockville, MD USA

[3] Ctr Dis Control & Prevent, Off Adv Mol Detect, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA

[4] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA

来源：

GENETICS IN MEDICINE | 2018年 / 20卷 / 06期

关键词：

genomics; precision medicine; precision public health; public health; FAMILIAL HYPERCHOLESTEROLEMIA; GENETIC TESTS; MEDICAL GENETICS; DISEASE-CONTROL; CANCER; PREVENTION; IMPACT; STATE; CARE; RECOMMENDATIONS;

D O I：

10.1038/gim.2017.211

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this paper, we review the evolution of the field of public health genomics in the United States in the past two decades. Public health genomics focuses on effective and responsible translation of genomic science into population health benefits. We discuss the relationship of the field to the core public health functions and essential services, review its evidentiary foundation, and provide examples of current US public health priorities and applications. We cite examples of publications to illustrate how Genetics in Medicine reflected the evolution of the field. We also reflect on how public-health genomics is contributing to the emergence of "precision public health" with near-term opportunities offered by the US Precision Medicine (AllofUs) Initiative.

引用

页码：574 / 582

页数：9

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