Apatite mineralization abilities and mechanical properties of covalently cross-linked pectin hydrogels

被引：17

作者：

Ichibouji, Takashi ^{[1
]}

Miyazaki, Toshiki ^{[1
]}

Ishida, Eiichi ^{[2
]}

Sugino, Atsushi ^{[3
]}

Ohtsuki, Chikara ^{[4
]}

机构：

[1] Kyushu Inst Technol, Grad Sch Life Sci & Syst Engn, Wakamatsu Ku, Kitakyushu, Fukuoka 8080196, Japan

[2] Kyushu Inst Technol, Fac Engn, Tobata Ku, Kitakyushu, Fukuoka 8048550, Japan

[3] Nakashima Med Co Ltd, Okayama 7008691, Japan

[4] Nagoya Univ, Grad Sch Engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2009年 / 29卷 / 06期

基金：

日本学术振兴会;

关键词：

Pectin; Apatite; Cross-linking; Simulated body fluid; Mechanical properties; SIMULATED BODY-FLUID; FORMING ABILITY; POLYAMIDE FILMS; GEL; DEPENDENCE; SILICA;

D O I：

10.1016/j.msec.2009.01.027

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Natural bone has features such as high fracture toughness and bone-bonding bioactivity, and is organic-inorganic hybrid composed of collagen and apatite crystals. Therefore, apatite-polymer hybrids designed to mimic the structure of bone represent candidates for high-performance bone substitutes. In this study, we prepared pectin hydrogels through covalent cross-linking using divinylsulfone (DVS) and investigated their apatite-forming abilities of the gels in simulated body fluid (SBF) and mechanical properties by tensile test. The obtained results were interpreted in terms of surface charge of the gels and chemical reaction with SBF. The apple- and citrus-derived gels formed the apatite on their surfaces in SBF within 3 days. These gels showed tensile strength around 30 MPa. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1765 / 1769

页数：5

共 26 条

[1] DEPENDENCE OF APATITE FORMATION ON SILICA-GEL ON ITS STRUCTURE - EFFECT OF HEAT-TREATMENT [J].