A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

被引：646
作者：
Lacronique, V
Boureux, A
DellaValle, V
Poirel, H
Quang, CT
Mauchauffe, M
Berthou, C
Lessard, M
Berger, R
Ghysdael, J
Bernard, OA
机构：
[1] INST GENET MOL, INSERM, U301, F-75010 PARIS, FRANCE
[2] INST GENET MOL, CNRS, SD 401 301, F-75010 PARIS, FRANCE
[3] CTR UNIV ORSAY, INST CURIE, SECT RECH, CNRS, UNITE MIXTE RECH 146, F-91405 ORSAY, FRANCE
[4] CTR HOSP REG BREST, HOP MORVAN, LAB CYTOGENET, UNITE HEMATOL, F-29609 BREST, FRANCE
来源：
SCIENCE | 1997年 / 278卷 / 5341期
关键词：
D O I：
10.1126/science.278.5341.1309
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Janus family of tyrosine kinases (JAK) plays an essential role in development and in coupling cytokine receptors to downstream intracellular signaling events. A t(9;12)(p24;p13) chromosomal translocation in a T cell childhood acute lymphoblastic leukemia patient was characterized and shown to fuse the 3' portion of JAK2 to the 5' region of TEL, a gene encoding a member of the ETS transcription factor family, The TEL-JAK2 fusion protein includes the catalytic domain of JAK2 and the TEL-specific oligomerization domain, TEL-induced oligomerization of TEL-JAK2 resulted in the constitutive activation of its tyrosine kinase activity and conferred cytokine-independent proliferation to the interleukin-3-dependent Ba/F3 hematopoietic cell line.
引用
收藏
页码：1309 / 1312
页数：4
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