In Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder

被引：41

作者：

Andrews, Derek Sayre ^{[1
]}

Avino, Thomas A. ^{[2
]}

Gudbrandsen, Maria ^{[1
]}

Daly, Eileen ^{[1
]}

Marquand, Andre ^{[3
,4
]}

Murphy, Clodagh M. ^{[1
,5
]}

Lai, Meng-Chuan ^{[6
,7
,8
,9
,10
]}

Lombardo, Michael V. ^{[6
,11
,12
]}

Ruigrok, Amber N. V. ^{[6
]}

Williams, Steven C. ^{[4
]}

Bullmore, Edward T. ^{[13
]}

Suckling, John ^{[14
]}

Baron-Cohen, Simon ^{[6
]}

Craig, Michael C. ^{[1
,5
]}

Murphy, Declan G. M. ^{[1
,5
]}

Ecker, Christine ^{[1
,14
]}

机构：

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Sackler Inst Translat Neurodev, Dept Forens & Neurodev Sci, London SE5 8AF, England

[2] Univ Calif Davis, Dept Psychiat & Behav Sci, MIND Inst, Sacramento, CA 95817 USA

[3] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands

[4] Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Neuroimaging Sci, London, England

[5] South London & Maudsley NHS Fdn Trust, Bethlem Royal Hosp, Natl Autism Unit, London, England

[6] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England

[7] Univ Toronto, Ctr Addict & Mental Hlth, Child & Youth Mental Hlth Collaborat, Toronto, ON, Canada

[8] Univ Toronto, Hosp Sick Children, Dept Psychiat, Toronto, ON, Canada

[9] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei, Taiwan

[10] Coll Med, Taipei, Taiwan

[11] Univ Cyprus, Dept Psychol, Nicosia, Cyprus

[12] Univ Cyprus, Ctr Appl Neurosci, Nicosia, Cyprus

[13] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge, England

[14] Goethe Univ Frankfurt Main, Univ Klinikum Frankfurt Main, Dept Child & Adolescent Psychiat Psychosomat & Ps, Frankfurt, Germany

来源：

CEREBRAL CORTEX | 2017年 / 27卷 / 02期

基金：

英国医学研究理事会;

关键词：

ASD; FreeSurfer; imaging; lamination; MRI; DORSOLATERAL PREFRONTAL CORTEX; TRANSIENT SUBPLATE ZONE; SURFACE-BASED ANALYSIS; CORTICAL THICKNESS; DEVELOPMENTAL HISTORY; NEURONAL DENSITY; BRAIN; MRI; ABNORMALITIES; ADULTS;

D O I：

10.1093/cercor/bhw404

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Atypical cortical organization and reduced integrity of the gray-white matter boundary have been reported by postmortem studies in individuals with autism spectrum disorder (ASD). However, there are no in vivo studies that examine these particular features of cortical organization in ASD. Hence, we used structural magnetic resonance imaging to examine differences in tissue contrast between gray and white matter in 98 adults with ASD and 98 typically developing controls, to test the hypothesis that individuals with ASD have significantly reduced tissue contrast. More specifically, we examined contrast as a percentage between gray and white matter tissue signal intensities (GWPC) sampled at the gray-white matter boundary, and across different cortical layers. We found that individuals with ASD had significantly reduced GWPC in several clusters throughout the cortex (cluster, P < 0.05). As expected, these reductions were greatest when tissue intensities were sampled close to gray-white matter interface, which indicates a less distinct gray-white matter boundary in ASD. Our in vivo findings of reduced GWPC in ASD are therefore consistent with prior postmortem findings of a less well-defined gray-white matter boundary in ASD. Taken together, these results indicate that GWPC might be utilized as an in vivo proxy measure of atypical cortical microstructural organization in future studies.

引用

页码：877 / 887

页数：11

共 57 条

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