[1] Univ Southampton, Fac Med, Southampton SO17 1BJ, Hants, England
[2] Univ Southampton, Inst Life Sci, Southampton SO17 1BJ, Hants, England
[3] Univ Hosp Southampton Fdn NHS Trust, Southampton NIHR Resp Biomed Res Unit, Southampton SO16 6YD, Hants, England
[4] Wellcome Trust Sanger Inst, Pathogen Genom, Hinxton CB10 1SA, England
[5] Univ Hosp Southampton Fdn NHS Trust, NIHR Wellcome Trust Clin Res Facil, Southampton SO16 6YD, Hants, England