Bacterial and Fungal Coinfection in Individuals With Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing

被引:1065
作者
Rawson, Timothy M. [1 ,2 ,3 ]
Moore, Luke S. P. [1 ,4 ,5 ]
Zhu, Nina [1 ]
Ranganathan, Nishanthy [3 ,4 ]
Skolimowska, Keira [3 ,4 ]
Gilchrist, Mark [3 ,4 ]
Satta, Giovanni [3 ,4 ]
Cooke, Graham [3 ,4 ]
Holmes, Alison [1 ,2 ,3 ,4 ]
机构
[1] Imperial Coll London, Natl Inst Hlth Res, Hlth Protect Res Unit Healthcare Associated Infec, London, England
[2] Imperial Coll London, Ctr Antimicrobial Optimisat, London, England
[3] Imperial Coll London, Dept Infect Dis, South Kensington, England
[4] Imperial Coll Healthcare NHS Trust, Hammersmith Hosp, London, England
[5] Chelsea & Westminster NHS Fdn Trust, London, England
关键词
SARS-CoV-2; antimicrobial stewardship; antimicrobial resistance; ACUTE RESPIRATORY SYNDROME; INTRAVENOUS ANTIBIOTICS; INFECTION; PNEUMONIA;
D O I
10.1093/cid/ciaa530
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. To explore and describe the current literature surrounding bacterial/fungal coinfection in patients with coronavirus infection. Methods. MEDLINE, EMBASE, and Web of Science were searched using broad-based search criteria relating to coronavirus and bacterial coinfection. Articles presenting clinical data for patients with coronavirus infection (defined as SARS-1, MERS, SARS-CoV-2, and other coronavirus) and bacterial/fungal coinfection reported in English, Mandarin, or Italian were included. Data describing bacterial/fungal coinfections, treatments, and outcomes were extracted. Secondary analysis of studies reporting antimicrobial prescribing in SARS-CoV-2 even in absence of coinfection was performed. Results. 1007 abstracts were identified. Eighteen full texts reporting bacterial/fungal coinfection were included. Most studies did not identify or report bacterial/fungal coinfection (85/140; 61%). Nine of 18 (50%) studies reported on COVID-19, 5/18 (28%) on SARS-1, 1/18 (6%) on MERS, and 3/18 (17%) on other coronaviruses. For COVID-19, 62/806 (8%) patients were reported as experiencing bacterial/fungal coinfection during hospital admission. Secondary analysis demonstrated wide use of broad-spectrum antibacterials, despite a paucity of evidence for bacterial coinfection. On secondary analysis, 1450/2010 (72%) of patients reported received antimicrobial therapy. No antimicrobial stewardship interventions were described. For non-COVID-19 cases, bacterial/fungal coinfection was reported in 89/815 (11%) of patients. Broad-spectrum antibiotic use was reported. Conclusions. Despite frequent prescription of broad-spectrum empirical antimicrobials in patients with coronavirus-associated respiratory infections, there is a paucity of data to support the association with respiratory bacterial/fungal coinfection. Generation of prospective evidence to support development of antimicrobial policy and appropriate stewardship interventions specific for the COVID-19 pandemic is urgently required.
引用
收藏
页码:2459 / 2468
页数:10
相关论文
共 50 条
[1]   Macrolides in critically ill patients with Middle East Respiratory Syndrome [J].
Arabi, Yaseen M. ;
Deeb, Ahmad M. ;
Al-Hameed, Fahad ;
Mandourah, Yasser ;
Almekhlafi, Ghaleb A. ;
Sindi, Anees A. ;
Al-Omari, Awad ;
Shalhoub, Sarah ;
Mady, Ahmed ;
Alraddadi, Basem ;
Almotairi, Abdullah ;
Al Khatib, Kasim ;
Abdulmomen, Ahmed ;
Qushmaq, Ismael ;
Solaiman, Othman ;
Al-Aithan, Abdulsalam M. ;
Al-Raddadi, Rajaa ;
Ragab, Ahmad ;
Al Harthy, Abdulrahman ;
Kharaba, Ayman ;
Jose, Jesna ;
Dabbagh, Tarek ;
Fowler, Robert A. ;
Balkhy, Hanan H. ;
Merson, Laura ;
Hayden, Frederick G. .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2019, 81 :184-190
[2]   Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State [J].
Arentz, Matt ;
Yim, Eric ;
Klaff, Lindy ;
Lokhandwala, Sharukh ;
Riedo, Francis X. ;
Chong, Maria ;
Lee, Melissa .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (16) :1612-1614
[3]   Extrapolation of mortality in COVID-19: Exploring the role of age, sex, co-morbidities and health-care related occupation [J].
Asfahan, Shahir ;
Deokar, Kunal ;
Dutt, Naveen ;
Niwas, Ram ;
Jain, Priyank ;
Agarwal, Mehul .
MONALDI ARCHIVES FOR CHEST DISEASE, 2020, 90 (02) :313-317
[4]   Covid-19 in Critically Ill Patients in the Seattle Region - Case Series [J].
Bhatraju, Pavan K. ;
Ghassemieh, Bijan J. ;
Nichols, Michelle ;
Kim, Richard ;
Jerome, Keith R. ;
Nalla, Arun K. ;
Greninger, Alexander L. ;
Pipavath, Sudhakar ;
Wurfel, Mark M. ;
Evans, Laura ;
Kritek, Patricia A. ;
West, T. Eoin ;
Luks, Andrew ;
Gerbino, Anthony ;
Dale, Chris R. ;
Goldman, Jason D. ;
O'Mahony, Shane ;
Mikacenic, Carmen .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (21) :2012-2022
[5]   Clinical Features and Short-term Outcomes of 102 Patients with Coronavirus Disease 2019 in Wuhan, China [J].
Cao, Jianlei ;
Tu, Wen-Jun ;
Cheng, Wenlin ;
Yu, Lei ;
Liu, Ya-Kun ;
Hu, Xiaoyong ;
Liu, Qiang .
CLINICAL INFECTIOUS DISEASES, 2020, 71 (15) :748-755
[6]   ORAL VERSUS INTRAVENOUS ANTIBIOTICS FOR COMMUNITY-ACQUIRED LOWER RESPIRATORY-TRACT INFECTION IN A GENERAL-HOSPITAL - OPEN, RANDOMIZED CONTROLLED TRIAL [J].
CHAN, R ;
HEMERYCK, L ;
OREGAN, M ;
CLANCY, L ;
FEELY, J .
BRITISH MEDICAL JOURNAL, 1995, 310 (6991) :1360-1362
[7]  
Chen L, 2020, Zhonghua Jie He He Hu Xi Za Zhi, V43, P203, DOI 10.3760/cma.j.issn.1001-0939.2020.03.013
[8]   Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study [J].
Chen, Nanshan ;
Zhou, Min ;
Dong, Xuan ;
Qu, Jieming ;
Gong, Fengyun ;
Han, Yang ;
Qiu, Yang ;
Wang, Jingli ;
Liu, Ying ;
Wei, Yuan ;
Xia, Jia'an ;
Yu, Ting ;
Zhang, Xinxin ;
Zhang, Li .
LANCET, 2020, 395 (10223) :507-513
[9]   Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial [J].
de Jong, Evelien ;
van Oers, Jos A. ;
Beishuizen, Albertus ;
Vos, Piet ;
Vermeijden, Wytze J. ;
Haas, Lenneke E. ;
Loef, Bert G. ;
Dormans, Tom ;
van Melsen, Gertrude C. ;
Kluiters, Yvette C. ;
Kemperman, Hans ;
van den Elsen, Maarten J. ;
Schouten, Jeroen A. ;
Streefkerk, Joern O. ;
Krabbe, Hans G. ;
Kieft, Hans ;
Kluge, Georg H. ;
van Dam, Veerle C. ;
van Pelt, Joost ;
Bormans, Laura ;
Otten, Martine Bokelman ;
Reidinga, Auke C. ;
Endeman, Henrik ;
Twisk, Jos W. ;
van de Garde, Ewoudt M. W. ;
de Smet, Anne Marie G. A. ;
Kesecioglu, Jozef ;
Girbes, Armand R. ;
Nijsten, Maarten W. ;
de lange, Dylan W. .
LANCET INFECTIOUS DISEASES, 2016, 16 (07) :819-827
[10]   Eleven faces of coronavirus disease 2019 [J].
Dong, Xiang ;
Cao, Yi-yuan ;
Lu, Xiao-xia ;
Zhang, Jin-jin ;
Du, Hui ;
Yan, You-qin ;
Akdis, Cezmi A. ;
Gao, Ya-dong .
ALLERGY, 2020, 75 (07) :1699-1709