Inhalation carcinogenicity of dichloromethane in rats and mice

被引：5

作者：

Aiso, Shigetoshi ^{[1
]}

Take, Makoto ^{[1
]}

Kasai, Tatsuya ^{[1
]}

Senoh, Hideki ^{[1
]}

Umeda, Yumi ^{[1
]}

Matsumoto, Michiharu ^{[1
]}

Fukushima, Shoji ^{[1
]}

机构：

[1] Japan Ind Safety & Hlth Assoc, Japan Bioassay Res Ctr, Hadano, Kanagawa 2570015, Japan

来源：

INHALATION TOXICOLOGY | 2014年 / 26卷 / 08期

关键词：

Carcinogenicity; dichloromethane; inhalation; rat; mouse; 2-YEAR DRINKING-WATER; METHYLENE-CHLORIDE; THETA; RODENTS; TRANSFERASES; ONCOGENICITY; TOXICITY; LIVER; MOUSE; LUNG;

D O I：

10.3109/08958378.2014.905660

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The carcinogenicity of inhaled dichloromethane (DCM) was examined by exposing groups of 50 F344/DuCrj rats and 50 Crj: BDF1 mice of both sexes to 0, 1000, 2000, or 4000 ppm (w/w) DCM-containing aerosol for 2 years. Inhalation of DCM resulted in increased incidences of subcutis fibromas, mammary gland fibroadenoma, and peritoneum mesotheliomas in male rats; mammary gland fibroadenomas in female rats; and bronchiolar-alveolar adenomas and carcinomas in the lung and hepatocellular adenomas and carcinomas in male and female mice. These results clearly indicate that inhaled DCM is carcinogenic in F344/DuCrj (SPF) rats and Crj: BDF1 (SPF) mice.

引用

页码：435 / 451

页数：17

共 30 条

[1]

[Anonymous], 1999, IARC Monogr Eval Carcinog Risks Hum, V71 Pt 1, P251

[2]

[Anonymous], DHEW PUBL

[3]

Bannasch P, 1986, IARC Sci Publ, P13

[4]

Boorman G.A., 1990, Pathology of the Fischer rat: reference and atlas, P295

[5] METHYLENE-CHLORIDE - A 2-YEAR INHALATION TOXICITY AND ONCOGENICITY STUDY IN RATS AND HAMSTERS [J].

BUREK, JD ;

NITSCHKE, KD ;

BELL, TJ ;

WACKERLE, DL ;

CHILDS, RC ;

BEYER, JE ;

DITTENBER, DA ;

RAMPY, LW ;

MCKENNA, MJ .

FUNDAMENTAL AND APPLIED TOXICOLOGY, 1984, 4 (01) :30-47

[6]

Japan Ministry of the Economy Trade and Industry, 2001, ACT AM MAN IMP ETC M

[7]

Japan Ministry of the Economy Trade and industry, 2011, ACT AM MAN IMP ETC M

[8]

Japan Ministry of the Environment, 2001, CHEM SUBST FACT SHEE

[9]

Japan Ministry of the Environment, 2011, CHEM SUBST FACT SHEE

[10] An exposure system for combined administration of an organic solvent to rodents by inhalation and water-drinking and its operational performance [J].

Kano, H ;

Goto, K ;

Suzuki, M ;

Yamazaki, K ;

Nishizawa, T ;

Arito, H ;

Yamamoto, S ;

Matsushima, T .

JOURNAL OF OCCUPATIONAL HEALTH, 2002, 44 (03) :119-124

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