A top-down view of the tumor microenvironment: structure, cells and signaling

被引：70
作者：
Bhome, Rahul [1 ,2 ]
Bullock, Marc D. [1 ,3 ]
Al Saihati, Hajir A. [1 ]
Goh, Rebecca W. [1 ]
Primrose, John N. [2 ]
Sayan, A. Emre [1 ]
Mirnezami, Alex H. [1 ,2 ]
机构：
[1] Univ Southampton, Fac Med, Canc Sci, Southampton, Hants, England
[2] Univ Southampton, Southampton Gen Hosp, Univ Surg, Southampton, Hants, England
[3] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2015年 / 3卷
关键词：
tumor microenvironment; cancer stroma; cancer-associated fibroblast; extracellular matrix; microRNA;
D O I：
10.3389/fcell.2015.00033
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create "activated" stroma. Equally, the extracellular matrix (ECM) contributes to tumor development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signaling components of the TME with a perspective on stromal soluble factors and microRNAs (miRNAs).
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