Novel nucleophilic substitution reactions of 5-halo-4-sulfur-substituted 5,6-dihydro-2-pyridones

被引：13

作者：

Chou, Shang-Shing P. ^{[1
]}

Hsieh, Hsin-I ^{[1
]}

Hung, Chia-Cheng ^{[1
]}

机构：

[1] Fu Jen Catholic Univ, Dept Chem, Taipei 242, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2006年 / 53卷 / 04期

关键词：

2-pyridones; nucleophilic substitution reactions; regioselectivity; aza-Diels-Alder reactions; DIELS-ALDER REACTIONS; SYNTHETIC APPLICATIONS; CYCLO-ADDITIONS; 1,3-DIENES;

D O I：

10.1002/jccs.200600119

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The title compounds (3, 8, 9 and 10) were efficiently synthesized, and their substitution reactions with various nucleophiles were carried out. The effects of leaving group, sulfur-substituent, solvent, reaction temperature, and the nature of the nucleophiles on the reactivity and S(N)2/S(N)2' regioselectivity were studied and rationalized with semi-empirical calculations.

引用

页码：891 / 900

页数：10

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