Sensitive quantification of chosen drugs by reversed-phase chromatography with electrochemical detection at a glassy carbon electrode

被引:45
作者
Chmielewska, Aleksandra [1 ]
Konieczna, Lucyna [1 ]
Plenis, Alina [1 ]
Lamparczyk, Henryk [1 ]
机构
[1] Med Univ Gdansk, Fac Pharm, PL-80416 Gdansk, Poland
来源
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2006年 / 839卷 / 1-2期
关键词
RP-HPLC/ECD; metoclopramide; hydrochlorothiazide; imipramine; diclofenac; pharmacokinetics;
D O I
10.1016/j.jchromb.2006.04.021
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Reversed-phase-high-performance liquid chromatographic method with electrochemical detection has proven to be a highly sensitive and selective method for determination of trace components in complex biological samples, and the electrochemical detector becomes an important alternative tool to ultraviolet and fluorescence detectors. A rapid and sensitive method for the accurate determination of metoclopramide, hydrochlorothiazide, imipramine and diclofenac in serum or plasma samples is described. The method is based on liquid-liquid extraction. The compounds were separated on C-18 column as stationary phase with a different binary mixture as mobile phase. Proposed method was validated with respect to specificity, linearity range, limit of detection and quantitation, precision, accuracy and successfully applied in a pharmacokinetic studies. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:102 / 111
页数:10
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