Discovery of PACAP and its receptors in the brain

被引：104
作者：
Hirabayashi, Takahiro [1 ]
Nakamachi, Tomoya [2 ]
Shioda, Seiji [1 ]
机构：
[1] Hoshi Univ, Global Res Ctr Innovat Life Sci, Peptide Drug Innovat, Shinagawa Ku, Tokyo 1428501, Japan
[2] Univ Toyama, Grad Sch Sci & Engn, Lab Regulatory Biol, 3190 Gofuku, Toyama, Toyama 9308555, Japan
来源：
JOURNAL OF HEADACHE AND PAIN | 2018年 / 19卷
关键词：
Neuropeptide; PACAP; PAC1-R; VPAC1-R; VPAC2-R; G protein-coupled receptors; Molecular cloning; CYCLASE-ACTIVATING POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE; IN-SITU HYBRIDIZATION; CEREBELLAR GRANULE CELLS; CENTRAL-NERVOUS-SYSTEM; PEPTIDE BINDING-SITES; ADENYLATE-CYCLASE; RAT-BRAIN; MOLECULAR-CLONING; FUNCTIONAL EXPRESSION;
D O I：
10.1186/s10194-018-0855-1
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (similar to 68%) to VIP. Because of the high homology of the amino acid sequences of PACAP and VIP, these peptides share three class B-G-protein coupled receptors: the PAC1-Receptor (PAC1-R), the VPAC1-Receptor (VPAC1-R) and VPAC2-Receptor (VPAC2-R). These receptors have high homology to each other, and their high homology is utilized for these discoveries. This review provides mainly an overview of the history of the discovery of PACAP and its three receptors.
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页数：8
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