Targeted therapies in non-small cell lung carcinoma: what have we achieved so far?

被引：44
作者：
Farhat, Fadi S. [1 ]
Houhou, Wissam [1 ]
机构：
[1] Hammoud Hosp Univ Med Ctr, Saida, Lebanon
来源：
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2013年 / 5卷 / 04期
关键词：
monoclonal antibody; non-small cell lung cancer; therapy; tyrosine kinase inhibitor; RANDOMIZED PHASE-II; PLATINUM-BASED CHEMOTHERAPY; ENDOTHELIAL GROWTH-FACTOR; PREVIOUSLY TREATED PATIENTS; ERLOTINIB MAINTENANCE THERAPY; ADVANCED SOLID MALIGNANCIES; NATIONAL-CANCER-INSTITUTE; TYROSINE KINASE INHIBITOR; PLACEBO-CONTROLLED TRIAL; BLP25 LIPOSOME VACCINE;
D O I：
10.1177/1758834013492001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The search for innovative therapeutic agents in non-small cell lung cancer (NSCLC) has witnessed a swift evolution. The number of targeted drugs that can improve patient outcomes with an acceptable safety profile is steadily increasing. In this review, we highlight current drugs that have already been approved or are under evaluation for the treatment of patients with NSCLC, either in monotherapy or combined therapy for both the first-and second-line settings. Experience with drugs targeting the vascular endothelial growth factor and its receptor, as well as the epidermal growth factor receptor is summarized. Moreover, we provide an overview of more novel targets in NSCLC and initial experience with the respective therapeutic agents.
引用
收藏
页码：249 / 270
页数：22
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