Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

被引：22

作者：

Allegra, Alessandro ^{[1
]}

Innao, Vanessa ^{[1
]}

Allegra, Andrea Gaetano ^{[1
]}

Pugliese, Marta ^{[1
]}

Di Salvo, Eleonora ^{[2
]}

Ventura-Spagnolo, Elvira ^{[3
]}

Musolino, Caterina ^{[1
]}

Gangemi, Sebastiano ^{[4
]}

机构：

[1] Univ Messina, Div Hematol, Dept Human Pathol Adulthood & Childhood Gaetano B, I-98125 Messina, Italy

[2] Inst Appl Sci & Intelligent Syst ISASI, Natl Res Council Italy CNR, I-98164 Messina, Italy

[3] Univ Palermo, Legal Med Sect, Dept Hlth Promot & Mother Child Care, I-90127 Palermo, Italy

[4] Univ Hosp G Martino, Sch & Div Allergy & Clin Immunol, Dept Clin & Expt Med, Via Consolare Valeria SNC, I-98125 Messina, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 11期

关键词：

monoclonal gammopathy of undetermined significance; multiple myeloma; T lymphocytes; cytokine; alarmin; inflammation; immunosurveillance; MESENCHYMAL STEM-CELLS; NECROSIS-FACTOR-ALPHA; SOLUBLE INTERLEUKIN-6 RECEPTOR; MARROW STROMAL CELLS; IL-33; PLASMA-LEVELS; CD8(+) T-CELLS; BONE-MARROW; SERUM-LEVELS; DENDRITIC CELLS; GROWTH-FACTOR;

D O I：

10.3390/ijms20112822

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs.

引用

页数：25

共 173 条

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