Engineering Phototheranostic Nanoscale Metal-Organic Frameworks for Multimodal Imaging-Guided Cancer Therapy

被引：303

作者：

Cai, Wen ^{[1
,2
]}

Gao, Haiyan ^{[2
]}

Chu, Chengchao ^{[2
]}

Wang, Xiaoyong ^{[2
]}

Wang, Junqing ^{[2
]}

Zhang, Pengfei ^{[2
]}

Lin, Gan ^{[2
]}

Li, Wengang ^{[2
]}

Liu, Gang ^{[2
]}

Chen, Xiaoyuan ^{[3
]}

机构：

[1] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Basic Med Sci, Inst Med Engn, Xian 710061, Shaanxi, Peoples R China

[2] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Ctr Mol Imaging & Translat Med, Xiamen 361102, Fujian, Peoples R China

[3] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 03期

基金：

中国国家自然科学基金;

关键词：

metal-organic frameworks (MOFs); indocyanine green; theranostic; bioimaging; photothermal therapy; INDOCYANINE-GREEN; PHOTOTHERMAL THERAPY; DRUG-DELIVERY; MAGNETIC-RESONANCE; TARGETED DELIVERY; PD NANOSHEETS; NANOPARTICLES; NANOMATERIALS; FLUORESCENCE; MIL-100(FE);

D O I：

10.1021/acsami.6b11579

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Many photoresponsive dyes have been utilized as imaging and photodynamic/photothermal therapy agents. Indocyanine green (ICG) is the only near-infrared region (NIR) organic dye for clinical applications approved by the United States Food and Drug Administration; however, the clinical application of ICG is limited by its poor aqueous solubility, low cancer specificity, and low sensitivity in cancer theranostics. To overcome these issues, a multifunctional nanoplatform based on hyaluronic acid (HA) and ICG-engineered metal-organic framework MIL-100(Fe) nanoparticles (MOF@HA@ICG NPs) was successfully developed for imaging-guided, anticancer photothermal therapy (PTT). The synthesized NPs showed a high loading content of ICG (40%), strong NIR absorbance, and photostability. The in vitro and in vivo imaging showed that the MOF@HA@ICG NPs exhibited greater cellular uptake in CD44-positive MCF-7 cells and enhanced tumor accumulation in xenograft tumors due to their targeting capability, compared to MOF@ICG NPs (non-HA-targeted) and free ICG. The in vitro photothermal toxicity and in vivo PTT treatments demonstrated that MOF@HA@ICG NPs could effectively inhibit the growth of MCF-7 cells/xenograft tumors. These results suggest that MOF@HA@ICG NPs could be served as a new promising theranostic nanoplatform for improved anticancer PTT through cancer-specific and image-guided drug delivery.

引用

页码：2040 / 2051

页数：12

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