New and practical method for synthesis of 1-and 1,3-substituted xanthines

被引：15

作者：

Zavialov, IA ^{[1
]}

Dahanukar, VH ^{[1
]}

Nguyen, H ^{[1
]}

Orr, C ^{[1
]}

Andrews, DR ^{[1
]}

机构：

[1] Schering Plough Res Inst, Dept Synthet Chem, Union, NJ 07083 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 13期

关键词：

D O I：

10.1021/ol049272n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and practical method for the synthesis of 1- and 1,3-substituted xanthines is reported. Direct base-promoted condensation of the imidazole precursor 1 with carbamates 2 gives 1-substituted 7-PMB xanthines 7 in good yields. Alkylation of these derivatives or their potassium salts proceeds under mild conditions to give functionalized 1,3-substituted 7-PMB xanthines 9 in good to excellent yields. The obtained 7-PMB-protected derivatives can be readily deprotected to give the parent 1- and 1,3-substituted xanthines.

引用

页码：2237 / 2240

页数：4

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