Obesity and NAFLD The Role of Bacteria and Microbiota

被引：75

作者：

Duseja, Ajay ^{[1
]}

Chawla, Yogesh Kumar ^{[1
]}

机构：

[1] Post Grad Inst Med Educ & Res, Dept Hepatol, Chandigarh 160012, India

来源：

CLINICS IN LIVER DISEASE | 2014年 / 18卷 / 01期

关键词：

Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Small intestinal bacterial overgrowth; Intestinal permeability; Endotoxemia; Toll-like receptors; Probiotics; NONALCOHOLIC FATTY LIVER; DIET-INDUCED OBESITY; TOLL-LIKE RECEPTORS; GUT MICROBIOTA; INTESTINAL PERMEABILITY; HEPATIC STEATOSIS; BINDING-PROTEIN; STEATOHEPATITIS; DISEASE; GLUCOSE;

D O I：

10.1016/j.cld.2013.09.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There are trillions of microorganisms in the human intestine collectively called gut microbiota. Obesity may be affected by the gut microbiota through energy harvesting and fat storage by the bacteria. Small intestinal bacterial overgrowth is also responsible for endotoxemia, systemic inflammation, and its consequences including obesity and nonalcoholic fatty liver disease (NAFLD). Relationship between gut microbiota and NAFLD is also dependent on altered choline and bile acid metabolism and endogenous alcohol production by gut bacteria. Further evidence linking gut microbiota with obesity and NAFLD comes from studies showing usefulness of probiotics in animals and patients with NAFLD. This article reviews the relationship among gut microbiota, obesity, and NAFLD.

引用

页码：59 / +

页数：14

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