Particle-based platforms for malaria vaccines

被引：24

作者：

Wu, Yimin ^{[1
]}

Narum, David L. ^{[1
]}

Fleury, Sylvain ^{[2
]}

Jennings, Gary ^{[3
]}

Yadava, Anjali ^{[4
]}

机构：

[1] NIAID, Lab Malaria Immunol & Vaccinol, Rockville, MD 20892 USA

[2] Mymetics Corp, CH-1066 Epalinges, Switzerland

[3] Cytos Biotechnol AG, CH-8952 Schlieren, Switzerland

[4] Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Vaccine Program, Silver Spring, MD USA

来源：

VACCINE | 2015年 / 33卷 / 52期

关键词：

Malaria; Vaccine; Particle; Delivery; Adjuvant; TRANSMISSION-BLOCKING VACCINE; AERUGINOSA EXOPROTEIN-A; IMMUNE-RESPONSES; ADJUVANT SYSTEM; THERAPEUTIC VACCINES; FALCIPARUM-MALARIA; EPITOPE DENSITY; IMMUNOGENICITY; CANDIDATE; DELIVERY;

D O I：

10.1016/j.vaccine.2015.09.097

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recombinant subunit vaccines in general are poor immunogens likely due to the small size of peptides and proteins, combined with the lack or reduced presentation of repetitive motifs and missing complementary signal(s) for optimal triggering of the immune response. Therefore, recombinant subunit vaccines require enhancement by vaccine delivery vehicles in order to attain adequate protective immunity. Particle-based delivery platforms, including particulate antigens and particulate adjuvants, are promising delivery vehicles for modifying the way in which immunogens are presented to both the innate and adaptive immune systems. These particle delivery platforms can also co-deliver non-specific immunostimodulators as additional adjuvants. This paper reviews efforts and advances of the Particle-based delivery platforms in development of vaccines against malaria, a disease that claims over 600,000 lives per year, most of them are children under 5 years of age in sub-Sahara Africa. (C) 2015 Elsevier Ltd.

引用

页码：7518 / 7524

页数：7

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