Effects of Omega-3 Fatty Acids on Inflammatory Markers in Cerebrospinal Fluid and Plasma in Alzheimer's Disease: The OmegAD Study

被引:78
作者
Freund-Levi, Yvonne [1 ]
Hjorth, Erik [2 ]
Lindberg, Catharina [2 ]
Cederholm, Tommy
Faxen-Irving, Gerd [3 ]
Vedin, Inger [4 ]
Palmblad, Jan [4 ]
Wahlund, Lars-Olof [1 ]
Schultzberg, Marianne [2 ]
Basun, Hans [5 ]
Jonhagen, Maria Eriksdotter [1 ]
机构
[1] Karolinska Univ Hosp, Div Clin Geriatr, Dept Neurobiol, Care Sci & Soc NVS, SE-14186 Huddinge, Sweden
[2] Karolinska Univ Hosp, Div Neurodegenerat, Dept Neurobiol, Care Sci & Soc NVS, SE-14186 Huddinge, Sweden
[3] Karolinska Univ Hosp, Div Clin Nutr, Dept Neurobiol, Care Sci & Soc NVS, SE-14186 Huddinge, Sweden
[4] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Div Haematol, SE-14186 Huddinge, Sweden
[5] Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden
关键词
Alzheimer's disease; Inflammation; Cerebrospinal fluid; omega-3 fatty acids; Cytokines; FATTY-ACID-COMPOSITION; RECEPTOR-TYPE-II; TAU; CYTOKINES; DEMENTIA; BRAIN; RISK; SUPPLEMENTATION; PREVENTION; DEPRESSION;
D O I
10.1159/000218081
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: omega-3 fatty acids (omega-3 FAs) found in dietary fish or fish oils are anti-inflammatory agents that may influence Alzheimer's disease (AD). Objective: To study the effects of dietary omega-3 FA supplementation on inflammatory markers in cerebrospinal fluid (CSF) and plasma from patients with mild to moderate AD. Methods: Thirty-five patients (70.3 +/- 8 8.2 years) were randomized to a daily intake of 2.3 g omega-3 FAs or placebo for 6 months. The inflammatory markers interleukin (IL)-6, tumour necrosis factor-alpha and soluble interleukin-1 receptor type II (sIL-1RII) were analysed in CSF and plasma at baseline and at 6 months. The AD markers tau-protein, hyperphosphorylated tau-protein and beta-amyloid (A beta(1-42)) were assessed in CSF. High-sensitivity C-reactive protein was assessed in plasma. A possible relation to the APOE genotype was investigated. Results: There was no significant treatment effect of omega-3 FAs on inflammatory and AD biomarkers in CSF or on inflammatory markers in plasma, nor was there any relation with APOE. A significant correlation was observed at baseline between sIL-1RII and A beta(1-42) levels in CSF. Conclusions: Treatment of AD patients with omega-3 FAs for 6 months did not influence inflammatory or biomarkers in CSF or plasma. The correlation between sIL-1RII and A beta(1-42) may reflect the reciprocal interactions between IL-1 and A beta peptides. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码:481 / 490
页数:10
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