Hepatocellular Carcinoma - Epidemiological Trends and Risk Factors

被引：386
作者：
Schuette, Kerstin [1 ]
Bornschein, Jan [1 ]
Malfertheiner, Peter [1 ]
机构：
[1] Otto VonGuericke Univ Magdegurg, Dept Gastroenterol Hepatol & Infect Dis, DE-39120 Magdeburg, Germany
来源：
DIGESTIVE DISEASES | 2009年 / 27卷 / 02期
关键词：
HCC; epidemiological trends; risk factors; Hepatocarcinogenesis; Viral hepatitis; Hepatitis B-associated HCC; Hepatitis C-associated HCC; Autoimmune hepatitis (AIH)-related HCC; HEPATITIS-C VIRUS; CHRONIC LIVER-DISEASE; HFE GENE-MUTATIONS; RETINOIC ACID CONCENTRATION; AFLATOXIN B-1 EXPOSURE; TERM-FOLLOW-UP; B E-ANTIGEN; NATURAL-HISTORY; INTERFERON THERAPY; NONALCOHOLIC STEATOHEPATITIS;
D O I：
10.1159/000218339
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide with about 600,000 patients dying from the disease annually. In 70-90%, HCC develops on the background of chronic liver cirrhosis or inflammation. Risk factors and etiologies vary among geographical regions. In regions with a high incidence the majority of cases are related to HBV and HCV hepatitis. In developed countries, in addition to virus-related HCC, high consumption of alcohol as well as non-alcoholic fatty liver disease often in the context of metabolic syndromes are the prevalent causes. Improvement in clinical management of patients with liver cirrhosis and the control of related complications are the key for the rising incidence of HCC. This review gives an overview on epidemiological trends and risk factors and their mechanisms involved in the hepatocarcinogenesis. Knowledge of these factors will help to improve current concepts for prevention, screening and treatment of this disease. Copyright (C) 2009 S. Karger AG, Basel
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页码：80 / 92
页数：13
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