Four homoverrucosane-type diterpenes from the marine sponge Halichondria sp

被引：4
作者：
Tian, Yong-Qi [2 ]
Gu, Bin-Bin [1 ]
Jiao, Wei-Hua [1 ]
Lin, Hou-Wen [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Ren Ji Hosp, Res Ctr Marine Drugs, Sch Med,Dept Pharm,State Key Lab Oncogenes & Rela, Shanghai 200127, Peoples R China
[2] Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China
来源：
TETRAHEDRON | 2020年 / 76卷 / 50期
关键词：
Halichondria sp. diterpenes; ECD spectroscopy; Cytotoxicity; SESQUITERPENE;
D O I：
10.1016/j.tet.2020.131697
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four new homoverrucosane-type diterpenes (1-4) and two known analogs (5-6) were isolated from the marine sponge Halichondria sp. Their structures including absolute configurations were determined by combination of spectroscopic analyses, theoretical calculations and comparison with data of literatures. The cytotoxicity against human multiple myeloma cell line RPMI-8266 of compounds 1-4 was evaluated, but none showed activity (IC50 > 10 mu M). It was the first report that homoverrucosanes isolated from the marine sponge Halichondria sp. (C) 2020 Published by Elsevier Ltd.
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页数：5
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