Quantification of left atrial strain and strain rate using Cardiovascular Magnetic Resonance myocardial feature tracking: a feasibility study

被引:213
作者
Kowallick, Johannes Tammo [1 ,8 ]
Kutty, Shelby [2 ,3 ]
Edelmann, Frank [4 ,8 ]
Chiribiri, Amedeo [5 ]
Villa, Adriana [5 ]
Steinmetz, Michael [6 ,8 ]
Sohns, Jan Martin [1 ,8 ]
Staab, Wieland [1 ,8 ]
Bettencourt, Nuno [7 ]
Unterberg-Buchwald, Christina [1 ,4 ,8 ]
Hasenfuss, Gerd [4 ,8 ]
Lotz, Joachim [1 ,8 ]
Schuster, Andreas [4 ,5 ,8 ]
机构
[1] Univ Gottingen, Inst Diagnost & Intervent Radiol, D-37073 Gottingen, Germany
[2] Creighton Univ, Univ Nebraska, Childrens Hosp, Omaha, NE 68178 USA
[3] Creighton Univ, Univ Nebraska, Med Ctr, Joint Div Pediat Cardiol, Omaha, NE 68178 USA
[4] Univ Gottingen, Dept Cardiol & Pneumol, D-37073 Gottingen, Germany
[5] Kings Coll London, St Thomas Hosp, Rayne Inst, Div Imaging Sci & Biomed Engn, London, England
[6] Univ Gottingen, Dept Pediat Cardiol & Intens Care Med, D-37073 Gottingen, Germany
[7] Ctr Hosp Gaia Espinho, Dept Cardiol, Vila Nova De Gaia, Portugal
[8] DZHK, German Ctr Cardiovasc Res, Gottingen, Germany
关键词
Cardiovascular magnetic resonance; Feature tracking; Diastolic dysfunction; Hypertrophic cardiomyopathy; Strain; Strain rate; Atrial physiology; HEART-FAILURE; HYPERTROPHIC CARDIOMYOPATHY; CONSENSUS STATEMENT; ECHOCARDIOGRAPHY; REPRODUCIBILITY; MECHANICS; VOLUMES; SOCIETY; SIZE; WALL;
D O I
10.1186/s12968-014-0060-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Cardiovascular Magnetic Resonance myocardial feature tracking (CMR-FT) is a quantitative technique tracking tissue voxel motion on standard steady-state free precession (SSFP) cine images to assess ventricular myocardial deformation. The importance of left atrial (LA) deformation assessment is increasingly recognized and can be assessed with echocardiographic speckle tracking. However atrial deformation quantification has never previously been demonstrated with CMR. We sought to determine the feasibility and reproducibility of CMR-FT for quantitative derivation of LA strain and strain rate (SR) myocardial mechanics. Methods: 10 healthy volunteers, 10 patients with hypertrophic cardiomyopathy (HCM) and 10 patients with heart failure and preserved ejection fraction (HFpEF) were studied at 1.5 Tesla. LA longitudinal strain and SR parameters were derived from SSFP cine images using dedicated CMR-FT software (2D CPA MR, TomTec, Germany). LA performance was analyzed using 4- and 2-chamber views including LA reservoir function (total strain [epsilon(s)], peak positive SR [SRs]), LA conduit function (passive strain [epsilon(e)], peak early negative SR [SRe]) and LA booster pump function (active strain [epsilon(a)], late peak negative SR [SRa]). Results: In all subjects LA strain and SR parameters could be derived from SSFP images. There was impaired LA reservoir function in HCM and HFpEF (epsilon(s) [%]: HCM 22.1 +/- 5.5, HFpEF 16.3 +/- 5.8, Controls 29.1 +/- 5.3, p < 0.01; SRs [s(-1)]: HCM 0.9 +/- 0.2, HFpEF 0.8 +/- 0.3, Controls 1.1 +/- 0.2, p < 0.05) and impaired LA conduit function as compared to healthy controls (epsilon(e) [%]: HCM 10.4 +/- 3.9, HFpEF 11.9 +/- 4.0, Controls 21.3 +/- 5.1, p < 0.001; SRe [s(-1)]: HCM -0.5 +/- 0.2, HFpEF -0.6 +/- 0.1, Controls -1.0 +/- 0.3, p < 0.01). LA booster pump function was increased in HCM while decreased in HFpEF (epsilon(a) [%]: HCM 11.7 +/- 4.0, HFpEF 4.5 +/- 2.9, Controls 7.8 +/- 2.5, p < 0.01; SRa [s(-1)]: HCM -1.2 +/- 0.4, HFpEF -0.5 +/- 0.2, Controls -0.9 +/- 0.3, p < 0.01). Observer variability was excellent for all strain and SR parameters on an intra- and inter-observer level as determined by Bland-Altman, coefficient of variation and intraclass correlation coefficient analyses. Conclusions: CMR-FT based atrial performance analysis reliably quantifies LA longitudinal strain and SR from standard SSFP cine images and discriminates between patients with impaired left ventricular relaxation and healthy controls. CMR-FT derived atrial deformation quantification seems a promising novel approach for the study of atrial performance and physiology in health and disease states.
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页数:9
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