Expression of ATP/GTP Binding Protein 1 Has Prognostic Value for the Clinical Outcomes in Non-Small Cell Lung Carcinoma

被引：3

作者：

Kwak, Hee Jeong ^{[1
]}

Gil, Minchan ^{[1
]}

Chae, Hee Sung ^{[1
]}

Seok, Jaekwon ^{[1
]}

Soundrarajan, Nagasundarapandian ^{[1
]}

Saha, Subbroto Kumar ^{[1
]}

Kim, Aram ^{[2
]}

Park, Kyoung Sik ^{[3
]}

Park, Chankyu ^{[1
]}

Cho, Ssang-Goo ^{[1
]}

机构：

[1] Konkuk Univ, Incurable Dis Anim Model & Stem Cell Inst IDASI, Dept Stem Cell & Regenerat Biotechnol, 120 Neungdong Ro, Seoul 05029, South Korea

[2] Konkuk Univ, Med Ctr, Sch Med, Dept Urol, Seoul 05029, South Korea

[3] Konkuk Univ, Sch Med, Med Ctr, Dept Surg, Seoul 05029, South Korea

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2020年 / 10卷 / 04期

关键词：

AGTPBP1; lung cancer; expression level; prognosis; patient survival; TUBULIN TYROSINE LIGASE; MICROTUBULE DYNAMICS; GENE-EXPRESSION; ALPHA-TUBULIN; BETA-TUBULIN; CANCER CELLS; WEB SERVER; DOXORUBICIN; APOPTOSIS; PATHWAY;

D O I：

10.3390/jpm10040263

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

ATP/GTP binding protein 1 (AGTPBP1) encodes a crucial protein, cytosolic carboxypeptidase 1 (CCP1), which plays a role in modulating the polyglutamylation of tubulin and has been studied in degenerative diseases. However, the role of AGTPBP1 in malignancy has not been completely studied yet. In this study, we examined the role of AGTPBP1 in cancer progression, its association with patient survival, and related mechanisms in lung cancer, using the A549 cell line and lung cancer gene expression datasets. AGTPBP1 knockdown increased the proliferation, migration, sphere formation, and drug resistance of A549 cells. Lung cancer datasets revealed significantly lower mRNA and protein expression levels of AGTPBP1 in lung cancer tissues, as compared to those in normal tissues. Importantly, AGTPBP1 expression positively correlated with patient survival. Analysis of co-expressed genes revealed that AGTPBP1 expression positively correlated with immune infiltration in lung cancer. Our results conclusively suggested that AGTPBP1 expression was correlated with cancer progression and immune infiltration in lung cancer.

引用

页码：1 / 22

页数：22

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