Glucose-responsive gene expression system for gene therapy

被引：8

作者：

Won, Jong Chul ^{[1
]}

Rhee, Byoung Doo ^{[1
]}

Ko, Kyung Soo ^{[1
]}

机构：

[1] Inje Univ, Coll Med,Sanggye Paik Hosp, Div Endocrinol & Metab, Dept Internal Med,Mitochondrial Res Grp, Seoul, South Korea

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2009年 / 61卷 / 7-8期

关键词：

Glucose-responsive gene; Insulin promoter; Carbohydrate responsive element binding protein; Gene therapy; PANCREATIC BETA-CELLS; ELEMENT-BINDING PROTEIN; PYRUVATE-KINASE GENE; HUMAN INSULIN-GENE; TRANSCRIPTION FACTOR PDX-1; PENTOSE-PHOSPHATE PATHWAY; FATTY-ACID SYNTHASE; OXIDATIVE STRESS; SKELETAL-MUSCLE; IN-VIVO;

D O I：

10.1016/j.addr.2009.03.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Regulation of gene expression by glucose is an important mechanism for mammals in adapting to their nutritional environment. Glucose, the primary fuel for most cells, modulates gene expression that is crucial in the cellular adaptation to glycemic variation. Transcription of the genes for insulin and glycolytic and lipogenic enzymes is stimulated by glucose in pancreatic beta-cells and liver. Recent findings further support the key role of the carbohydrate-responsive element binding protein in the regulation of glycolytic and lipogenic genes by glucose and dietary carbohydrates. Herein, we review the transcriptional regulation of glucose-responsive genes, and recent advances in the gene therapy using glucose-responsive gene expression for diabetes. (C) 2009 Published by Elsevier B.V.

引用

页码：633 / 640

页数：8

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