Synthesis of methyl-5-[2-arylamino-4-(3-oxo-1,4-benzoxazin-6-yl)thiazole acetates and 7H-[3-aryl-6-(3-oxo-1,4-benzoxazin-6-yl)-s-triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetates as possible COX-2-inhibitors

被引：0

作者：

Reddy, G. Jagath

Rao, K. Srinivasa

机构：

[1] Dr Jagath Reddys Heterocycl, R&D Labs, Hyderabad 500037, Andhra Pradesh, India

[2] Jawaharlal Nehru Technol Univ, Oil Technol Res Inst, Anantapur 515001, Andhra Pradesh, India

[3] Univ Hyderabad, Sch Life Sci, Hyderabad 500046, Andhra Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2006年 / 45卷 / 09期

关键词：

benzoxazin; nu-bromobenzoxazinyl butanoate; thiazolylbenzoxazinyl acetates; triazolothiadiazinyl benzoxazinyl acetate; COX-2; inhibitors;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of methyl 5-[2-arylamino-4-(3-oxo-[1,4]beilzoxazin-6-yl)thiazoleacetates 5a-h and 7H-[3-aryl-6-(3-oxo-[1,4]-benzoxazin-6-yl)-s-triazolo[3,4-b] [ 1,3,4] thiadiazin-7-yl] acetates 6a-e have been synthesized and tested for their COX-2 inhibitor activity.

引用

页码：2143 / 2146

页数：4

共 44 条

[31] Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters
Sharma, Sandeep Kumar
Kumar, Pradeep
Narasimhan, Balasubramanian
Ramasamy, Kalavathy
Mani, Vasudevan
Mishra, Rakesh Kumar
Majeed, Abu Bakar Abdul
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 48 : 16 - 25
[32] Synthesis and antimicrobial screening of novel 9-{2-[(1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives
Kumar, A. Kishore
Sunitha, V.
Shankar, B.
Krishna, T. Murali
Lincoln, Ch. Abraham
Jalapathi, P.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (09) : 2011 - 2020
[33] Crystal structure of N,N-dimethyl-N'-(2-methyl-4-oxo-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d] pyrimidin-3(4H)-yl)formimidamide,C14H18N4OS
Al-Jaeed, Nada
Lahsasni, Siham
Ghabbour, Hazem A.
El-Sayed, Nahed N. E.
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2017, 232 (02): : 217 - 219
[34] Efficient One-Pot Synthesis, Structure Elucidation, and Antibacterial Activities of Novel 3-(Adamantan-1-yl)-1-alkyl(aryl, aralkyl, hydroxyethyl)-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazolin-5-ones
Kaping, S.
Kalita, U.
Rajkumari, S.
Sen, A.
Vishwakarma, J. N.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 58 (01) : 152 - 158
[35] Synthesis of 2-methyl-3-(2-(piperazin-1-yl)ethyl)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one Derivatives as Antimicrobial Agents
Krishnamurthy, Byregowda
Vinaya, Kambappa
Prasanna, Doddakunche S.
Raghava, Byregowda
Rangappa, Kanchugarakoppal S.
LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (10) : 988 - 995
[36] Water mediated synthesis of 6-amino-5-cyano-2-oxo-N-(pyridin-2-yl)-4-(p-tolyl)-2H-[1,2′-bipyridine]-3-carboxamide and 6-amino-5-cyano-4-(4-fluorophenyl)-2-oxo-N-(pyridin-2-yl)-2H-[1,2′-bipyridine]-3-carboxamide - An experimental and computational studies with non-linear optical (NLO) and molecular docking analyses
Jayarajan, Ramasamy
Satheeshkumar, Rajendran
Kottha, Thirumalaswamy
Subbaramanian, Sabarinathan
Sayin, Koray
Vasuki, Gnanasambandam
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2020, 229 (229)
[37] Ultrasound-assisted synthesis of 3-(1-(2-(1H-indol-3-yl)ethyl)-2-aryl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)indolin-2-ones by novel core-shell bio-based nanocatalyst anchoring sulfonated L-histidine on magnetized silica (SO3H-L-His@SiO2-nano Fe3O4)
Nikoofar, Kobra
Peyrovebaghi, Seyedeh S.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2020, 67 (07) : 1303 - 1313
[38] An efficient synthesis of 16H-dibenzo[2,3:6,7][1,4]oxazepino[5,4-b]quinazolin-16-ones via an Ullmann reaction catalyzed by CuI
Zhang, Yan
Liu, Jian-Quan
Wang, Xiang-Shan
ORGANIC & BIOMOLECULAR CHEMISTRY, 2018, 16 (10) : 1679 - 1685
[39] Synthesis, antimicrobial, and mosquito larvicidal activity of 1-aryl-4-methyl-3,6-bis-(5-methylisoxazol-3-yl)-2-thioxo-2,3,6,10b-tetrahydro-1H-pyrimido[5,4-c]quinolin-5-ones
Rajanarendar, E.
Reddy, M. Nagi
Murthy, K. Rama
Reddy, K. Govardhan
Raju, S.
Srinivas, M.
Praveen, B.
Rao, M. Srinivasa
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (20) : 6052 - 6055
[40] Selective multicomponent 'one-pot' approach to the new 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)chromeno[2,3-b]pyridine scaffold in pyridine-ethanol catalyst/solvent system
Elinson, Michail N.
Vereshchagin, Anatoly N.
Anisina, Yuliya E.
Krymov, Stepan K.
Fakhrutdinov, Artem N.
Egorov, Mikhail P.
MONATSHEFTE FUR CHEMIE, 2019, 150 (06): : 1073 - 1078

← 1 2 3 4 5 →