Human hair keratin-associated proteins (KAPs)

被引：190
作者：
Rogers, Michael A. [1 ]
Langbein, Lutz
Praetzel-Wunder, Silke
Winter, Hermelita
Schweizer, Juergen
机构：
[1] German Canc Res Ctr, Sect Normal & Neoplast Epidermal Differentiat, D-6900 Heidelberg, Germany
[2] German Canc Res Ctr, Div Cell Biol, D-6900 Heidelberg, Germany
来源：
INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 251 | 2006年 / 251卷
关键词：
keratin-associated protein; hair follicle; gene expression; polymorphisrn; keratin; genodermatosis;
D O I：
10.1016/S0074-7696(06)51006-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Elucidation of the genes encoding structural proteins of the human hair follicle has advanced rapidly during the last decade, complementing nearly three previous decades of research on this subject in other species. Primary among these advances was both the characterization of human hair keratins, as well as the hair keratin associated proteins (KAPs). This review describes the currently known human KAP families, their genomic organization, and their characteristics of expression. Furthermore, this report delves into further aspects, such as polymorphic variations in human KAP genes, the role that KAP proteins might play in hereditary hair diseases, as well as their modulation in several different transgenic mouse models displaying hair abnormalities.
引用
收藏
页码：209 / +
页数：64
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