Human hair keratin-associated proteins (KAPs)

被引：190
作者：
Rogers, Michael A. [1 ]
Langbein, Lutz
Praetzel-Wunder, Silke
Winter, Hermelita
Schweizer, Juergen
机构：
[1] German Canc Res Ctr, Sect Normal & Neoplast Epidermal Differentiat, D-6900 Heidelberg, Germany
[2] German Canc Res Ctr, Div Cell Biol, D-6900 Heidelberg, Germany
来源：
INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 251 | 2006年 / 251卷
关键词：
keratin-associated protein; hair follicle; gene expression; polymorphisrn; keratin; genodermatosis;
D O I：
10.1016/S0074-7696(06)51006-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Elucidation of the genes encoding structural proteins of the human hair follicle has advanced rapidly during the last decade, complementing nearly three previous decades of research on this subject in other species. Primary among these advances was both the characterization of human hair keratins, as well as the hair keratin associated proteins (KAPs). This review describes the currently known human KAP families, their genomic organization, and their characteristics of expression. Furthermore, this report delves into further aspects, such as polymorphic variations in human KAP genes, the role that KAP proteins might play in hereditary hair diseases, as well as their modulation in several different transgenic mouse models displaying hair abnormalities.
引用
收藏
页码：209 / +
页数：64
相关论文
共 148 条
[111]   THE NEIGHBOR-JOINING METHOD - A NEW METHOD FOR RECONSTRUCTING PHYLOGENETIC TREES [J].
SAITOU, N ;
NEI, M .
MOLECULAR BIOLOGY AND EVOLUTION, 1987, 4 (04) :406-425
[112]   A common protein interaction domain links two recently identified epilepsy genes [J].
Scheel, H ;
Tomiuk, S ;
Hofmann, K .
HUMAN MOLECULAR GENETICS, 2002, 11 (15) :1757-1762
[113]   The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system [J].
Schlake, T ;
Schorpp, M ;
Nehls, M ;
Boehm, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3842-3847
[114]  
Schlake T, 2000, DEV DYNAM, V217, P368, DOI 10.1002/(SICI)1097-0177(200004)217:4<368::AID-DVDY4>3.0.CO
[115]  
2-Z
[116]   Hoxc12 expression pattern in developing and cycling murine hair follicles [J].
Shang, L ;
Pruett, ND ;
Awgulewitsch, A .
MECHANISMS OF DEVELOPMENT, 2002, 113 (02) :207-210
[117]   Comparative genomics of the keratin-associated protein (KAP) gene clusters in human, chimpanzee, and baboon [J].
Shibuya, K ;
Kudoh, J ;
Obayashi, I ;
Shimizu, A ;
Sasaki, T ;
Minoshima, S ;
Shimizu, N .
MAMMALIAN GENOME, 2004, 15 (03) :179-192
[118]   A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 2lq22.3 [J].
Shibuya, K ;
Obayashi, I ;
Asakawa, S ;
Minoshima, S ;
Kudoh, J ;
Shimizu, N .
GENOMICS, 2004, 83 (04) :679-693
[119]   Characterization of human keratin-associated protein 1 family members [J].
Shimomura, Y ;
Aoki, N ;
Rogers, MA ;
Langbein, L ;
Schweizer, J ;
Ito, M .
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 2003, 8 (01) :96-99
[120]   Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family [J].
Shimomura, Y ;
Aoki, N ;
Schweizer, J ;
Langbein, L ;
Rogers, MA ;
Winter, H ;
Ito, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) :45493-45501
6789101112131415