Effect of insulin resistance on hepatic function in type 2 diabetes

被引：0
|
作者：
El Oudi, M. [1 ]
Ouertani, H. [2 ]
Aouni, Z. [1 ]
Mazigh, C. [1 ]
Zidi, B. [2 ]
Machghoul, S. [1 ]
机构：
[1] Hop Mil Principal Instruct Tunis, Dept Biochim, Tunis, Tunisia
[2] Hop Mil Principal Instruct Tunis, Dept Endocrinol, Tunis, Tunisia
来源：
IMMUNO-ANALYSE & BIOLOGIE SPECIALISEE | 2009年 / 24卷 / 03期
关键词：
Type; 2; diabetes; Hepatic enzymes; Insulin resistance; ALANINE AMINOTRANSFERASE;
D O I：
10.1016/j.immbio.2009.03.001
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Introduction. - Nowadays the role of liver in the development of type 2 diabetes presents an interest in the recent studies research. Objectives. - In the present study we intend to determine the relationship between hepatic enzymes and insulinresistance in type 2 diabetic patients. Material and method. - The study group consists of 68 diabetics subdivided into two sub-groups: insulinsensitive diabetics (n = 26) and insulin resistant diabetics (n = 42) and a group of 24 control subjects. Results. - Diabetics have significant elevated levels of Alat (p = 0.03), Asat (p = 0.02) and GGT (p = 0.03) when compared to control subjects. Insulinresistant diabetics present the highest levels of hepatic enzymes Asat, Alat and GGT when compared to insulinsensitive diabetics. Conclusion. - Insuline may play a role in the hepatic function. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：121 / 125
页数：5
相关论文
共 50 条
  • [1] Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance
    Cree-Green, Melanie
    Wiromrat, Pattara
    Stuppy, Jacob J.
    Thurston, Jessica
    Bergman, Bryan C.
    Baumgartner, Amy D.
    Bacon, Samantha
    Scherzinger, Ann
    Pyle, Laura
    Nadeau, Kristen J.
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2019, 316 (02): : E186 - E195
  • [2] Associations of pancreatic β-cell function and insulin resistance with microalbuminuria in type 2 diabetes
    Sun, Xun
    Xiao, Ye
    Wang, Bin
    Lv, Wen-shan
    Liu, Ying
    Chen, Ying
    Wang, Yan-gang
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2015, 110 (03) : E22 - E26
  • [3] Myokines in insulin resistance and type 2 diabetes
    Eckardt, Kristin
    Gorgens, Sven W.
    Raschke, Silja
    Eckel, Juergen
    DIABETOLOGIA, 2014, 57 (06) : 1087 - 1099
  • [4] PPARs, insulin resistance and type 2 diabetes
    Kaplan, F
    Al-Majali, K
    Betteridge, DJ
    JOURNAL OF CARDIOVASCULAR RISK, 2001, 8 (04): : 211 - 217
  • [5] Insulin resistance and type 2 diabetes in children
    Castorani, Valeria
    Polidori, Nella
    Giannini, Cosimo
    Blasetti, Annalisa
    Chiarelli, Francesco
    ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2020, 25 (04) : 217 - 226
  • [6] Biomarkers for Assessing Beta-Cell Function and Insulin Resistance in Type 2 Diabetes
    Pfuetzner, A.
    Weber, M. M.
    Forst, T.
    DIABETES STOFFWECHSEL UND HERZ, 2008, 17 : S37 - S41
  • [7] Mechanism and Effect of Yam Polysaccharides on Insulin Resistance in Type 2 Diabetes Mice
    Guan Q.
    Yi H.
    Lü B.
    Zheng Z.
    Chen X.
    Bao C.
    Han N.
    Journal of Food Science and Technology (China), 2023, 41 (03): : 64 - 71
  • [8] Potential berberine effect in the insulin resistance prevention and type 2 diabetes treatment
    Mroz, Michalina
    Pastusiak, Katarzyna
    Bogdanski, Pawel
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2021, 75 (01): : 790 - 801
  • [9] Cognitive function and insulin resistance in elderly patients with type 2 diabetes
    Ma, Lina
    Li, Yun
    NEUROLOGICAL RESEARCH, 2017, 39 (03) : 259 - 263
  • [10] Visceral Adiposity, Insulin Resistance, and Type 2 Diabetes
    Griffith, Michelle L.
    Younk, Lisa M.
    Davis, Stephen N.
    AMERICAN JOURNAL OF LIFESTYLE MEDICINE, 2010, 4 (03) : 230 - 243
12345