Brain plasticity effects of neuromodulation against multiple sclerosis fatigue

被引：45

作者：

Tecchio, Franca ^{[1
,2
]}

Cancelli, Andrea ^{[1
,3
]}

Cottone, Carlo ^{[1
]}

Ferrucci, Roberta ^{[4
,5
]}

Vergari, Maurizio ^{[4
,5
]}

Zito, Giancarlo ^{[1
,6
]}

Pasqualetti, Patrizio ^{[2
,6
]}

Filippi, Maria Maddalena ^{[6
]}

Ghazaryan, Anna ^{[1
,6
]}

Lupoi, Domenico ^{[6
]}

Smits, Fenne M. ^{[7
]}

Giordani, Alessandro ^{[3
,6
]}

Migliore, Simone ^{[8
]}

Porcaro, Camillo ^{[1
,9
]}

Salustri, Carlo ^{[1
]}

Rossini, Paolo M. ^{[2
,3
]}

Priori, Alberto ^{[4
,5
]}

机构：

[1] CNR, Lab Elect Translat Neurosci LETS, Dept Neurosci, ISTC,Fatebenefratelli Hosp Isola Tiberina, Rome, Italy

[2] IRCCS San Raffaele Pisana, Unit Neuroimaging, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Neurol Clin, Policlin A Gemelli, I-00168 Rome, Italy

[4] Univ Milan, Fdn IRCCS Ca Granda, Milan, Italy

[5] Univ Milan, Osped Maggiore Policlin, Milan, Italy

[6] Fatebenefratelli Fdn Hlth Res & Educ, AFaR Div, Rome, Italy

[7] Univ Amsterdam, Amsterdam, Netherlands

[8] Univ Campus Biomed, Psychol Serv, Rome, Italy

[9] Newcastle Univ, Inst Neurosci, Sch Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

FRONTIERS IN NEUROLOGY | 2015年 / 6卷

关键词：

fatigue in multiple sclerosis; electroencephalography; transcranial magnetic stimulation; transcranial direct current stimulation; magnetic resonance imaging; electrode personalization; DIRECT-CURRENT STIMULATION; MAGNETIC STIMULATION; EVOKED-POTENTIALS; SPINAL-CORD; EXCITATION; INHIBITION; TRIAL;

D O I：

10.3389/fneur.2015.00141

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Rationale: We recently reported on the efficacy of a personalized transcranial direct current stimulation (tDCS) treatment in reducing multiple sclerosis (MS) fatigue. The result supports the notion that interventions targeted at modifying abnormal excitability within the sensorimotor network could represent valid non-pharmacological treatments. Objective: The present work aimed at assessing whether the mentioned intervention also induces changes in the excitability of sensorimotor cortical areas. Method: Two separate groups of fatigued MS patients were given a 5-day tDCS treatments targeting, respectively, the whole body somatosensory areas (S1(wb)) and the hand sensorimotor areas (SM1(hand)). The study had a double blind, sham-controlled, randomized, cross-over (Real vs. Sham) design. Before and after each treatment, we measured fatigue levels (by the modified fatigue impact scale, mFIS), motor evoked potentials (MEPs) in response to transcranial magnetic stimulation and somatosensory evoked potentials (SEPs) in response to median nerve stimulation. We took MEPs and SEPs as measures of the excitability of the primary motor area (M1) and the primary somatosensory area (51), respectively. Results: The Real S1(wb) treatment produced a 27% reduction of the mFIS baseline level, while the SM1(hand) treatment showed no difference between Real and Sham stimulations. M1 excitability increased on average 6% of the baseline in the S1(wb) group and 40% in the SM1(hand) group. Observed SEP changes were not significant and we found no association between M1 excitability changes and mFIS decrease. Conclusion: The tDCS treatment was more effective against MS fatigue when the electrode was focused on the bilateral whole body somatosensory area. Changes in 51 and M1 excitability did not correlate with symptoms amelioration. Significance: The neuromodulation treatment that proved effective against MS fatigue induced only minor variations of the motor cortex excitability, not enough to explain the beneficial effects of the intervention.

引用

页数：8

共 37 条

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