Endocrine Sequelae in Childhood Cancer Survivors

被引：7

作者：

George, Sobenna A. ^{[1
]}

Effinger, Karen E. ^{[2
,3
]}

Meacham, Lillian R. ^{[1
,2
,3
]}

机构：

[1] Emory Univ, Dept Pediat, Div Endocrinol, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Pediat, Div Hematol Oncol BMT, 2015 Uppergate Dr Northeast,4th Floor, Atlanta, GA 30322 USA

[3] Childrens Healthcare Atlanta, Aflac Canc & Blood Disorders Ctr, Atlanta, GA USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2020年 / 49卷 / 04期

关键词：

Childhood cancer survivors; Endocrine late effects; Surveillance; Endocrinopathy; LONG-TERM SURVIVORS; ALKYLATING AGENT EXPOSURE; THERAPY-A-REPORT; ADULT SURVIVORS; OVARIAN INSUFFICIENCY; PEDIATRIC-PATIENTS; RADIATION-THERAPY; CHILDREN; HORMONE; RISK;

D O I：

10.1016/j.ecl.2020.07.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The 5-year survival rate for childhood cancer survivors is currently greater than 80% in developed countries. However, survivors may have an increased risk of endocrine toxicities from their tumors or their treatments. Although some endocrinopathies are apparent soon after cancer therapy completion, others manifest years later; therefore, long-term surveillance is crucial. This article reviews the association between cancer treatments and endocrine late effects. It also summarizes recommendations regarding surveillance for endocrine late effects and referrals to endocrinologists based on treatment exposures. In addition, this article provides special considerations for the treatment of endocrinopathies in survivors.

引用

页码：565 / +

页数：24

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