Phosphorylation of Helicobacter pylori CagA in patients with gastric ulcer and gastritis

被引：2

作者：

Cheng, KS ^{[1
]}

Lu, MC ^{[1
]}

Tang, HL ^{[1
]}

Chou, FT ^{[1
]}

机构：

[1] China Med Coll Hosp, Dept Internal Med, Div Gastroenterol, Taichung 40421, Taiwan

来源：

ADVANCES IN THERAPY | 2002年 / 19卷 / 02期

关键词：

type IV phosphorylation; pathogenicity island; gastritis; gastric ulcer;

D O I：

10.1007/BF02850057

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of Helicobacter pylori infection are strongly associated with chronic gastritis, gastric and duodenal ulcer, gastric cancer, and MALT lymphoma. The microorganism has been classified as a type I carcinogen by the World Health Organization. Varying clinical results from H. pylori infection are believed due, in part, to differences in virulence among species. The cag pathogenicity island is a complex of virulent genes and a coding region for the type IV phosphorylated secretion system. Through this system, many virulent gene products or proteins are phosphorylated into the host cells. This study demonstrated the positive CagA-phosphorylation effect of H. pylori in patients with chronic gastritis and benign gastric ulcer and revealed significantly different rates of CagA phosphorylation between these two diseases (P<.05).

引用

页码：85 / 90

页数：6

共 50 条

[31] Helicobacter pylori infection and gastric function in patients with fundic atrophic gastritis
Tucci, A
Poli, L
Biasco, G
Paparo, GF
Tosetti, C
Fusaroli, P
Sambri, V
Donati, M
Grigioni, W
Labate, AMM
Stanghellini, V
Caletti, G
DIGESTIVE DISEASES AND SCIENCES, 2001, 46 (07) : 1573 - 1583
[32] An East-Asian-type cagA Helicobacter pylori Infected Patient with Clinical Manifestation of Gastric Ulcer
Rezkitha, Yudith A. A.
Miftahussurur, Muhammad
Nusi, Iswan A.
Maimunah, Ummi
Adi, Pangestu
Yamaoka, Yoshio
ACTA MEDICA INDONESIANA, 2016, 48 (04) : 307 - 313
[33] Gastric ulcer, atrophic gastritis, and intestinal metaplasia caused by Helicobacter pylori infection in Mongolian gerbils
Honda, S
Fujioka, T
Tokieda, M
Gotoh, T
Nishizono, A
Nasu, M
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1998, 33 (05) : 454 - 460
[34] Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells
Gobert, Alain P.
Verriere, Thomas
de Sablet, Thibaut
Peek, Richard M., Jr.
Chaturvedi, Rupesh
Wilson, Keith T.
CELLULAR MICROBIOLOGY, 2013, 15 (01) : 145 - 156
[35] E-Cadherin Protein as a Potential Marker for Gastric Cancer and Its Association with Helicobacter Pylori- Induced Gastritis and Gastric Ulcer
Al-Bayaty, Mustafa Kahtan
Abass, Salma Abdul-Rudha
Al-Marjani, Mohammed Faraj
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2019, 8 (03): : 269 - 277
[36] Th response to Helicobacter pylori differs between patients with gastric ulcer and duodenal ulcer
Itoh, T
Seno, H
Kita, T
Chiba, T
Wakatsuki, Y
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2005, 40 (06) : 641 - 647
[37] EFFECT OF SUCRALFATE ON HELICOBACTER-PYLORI AND SEVERITY OF GASTRITIS IN PATIENTS WITH DUODENAL-ULCER
WINTER, TA
LOUW, JA
MARKS, IN
JASKIEWICZ, K
LUCKE, W
CALLANAN, M
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1995, 30 : 85 - 88
[38] Low prevalence of monoclonal B cells in Helicobacter pylori gastritis patients with duodenal ulcer
de Mascarel, A
Dubus, P
Belleanée, G
Megraud, F
Merlio, JP
HUMAN PATHOLOGY, 1998, 29 (08) : 784 - 790
[39] Risk factors for early gastric cancer: focus on Helicobacter pylori gastritis
Moon, Hee Seok
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, 2022, 65 (05): : 259 - 266
[40] Characteristics of gastric cancer in peptic ulcer patients with Helicobacter pylori infection
Hwang, Jae Jin
Lee, Dong Ho
Lee, Ae-Ra
Yoon, Hyuk
Shin, Cheol Min
Park, Young Soo
Kim, Nayoung
WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (16) : 4954 - 4960

← 1 2 3 4 5 →