Cell-derived microparticles in haemostasis and vascular medicine

被引:329
作者
Burnier, Laurent [1 ,2 ]
Fontana, Pierre [3 ,4 ]
Kwak, Brenda R. [4 ,5 ]
Angelillo-Scherrer, Anne [1 ,2 ]
机构
[1] CHU Vaudois, Serv & Cent Lab Hematol, CH-1011 Lausanne, Switzerland
[2] Univ Lausanne, Lausanne, Switzerland
[3] Univ Hosp Geneva, Div Angiol & Haemostasis, Geneva, Switzerland
[4] Univ Geneva, Geneva, Switzerland
[5] Univ Hosp Geneva, Div Cardiol, Geneva, Switzerland
关键词
Microparticle; ectosome; haemostasis; vascular pathologies; COMPLEMENT PROTEINS C5B-9; THROMBOTIC THROMBOCYTOPENIC PURPURA; HEPARIN-INDUCED THROMBOCYTOPENIA; INDUCED PLATELET MICROPARTICLES; SHED MEMBRANE MICROPARTICLES; TISSUE FACTOR; ENDOTHELIAL MICROPARTICLES; PROCOAGULANT ACTIVITY; CIRCULATING MICROPARTICLES; SCOTT-SYNDROME;
D O I
10.1160/TH08-08-0521
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Considerable interest for cell-derived microparticles has emerged, pointing out their essential role in haemostatic response and their potential as disease markers, but also their implication in a wide range of physiological and pathological processes. They derive from different cell types including platelets the main source of microparticles - but also from red blood cells, leukocytes and endothelial cells, and they circulate in blood. Despite difficulties encountered in analyzing them and disparities of results obtained with a wide range of methods, microparticle generation processes are now better understood. However, a generally admitted definition of microparticles is currently lacking. For all these reasons we decided to review the literature regarding microparticles in their widest definition, including ectosomes and exosomes, and to focus mainly on their role in haemostasis and vascular medicine.
引用
收藏
页码:439 / 451
页数:13
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