Biology of IL-36 cytokines and their role in disease

被引：153

作者：

Gresnigt, Mark S. ^{[1
,2
]}

van de Veerdonk, Frank L. ^{[1
,2
,3
]}

机构：

[1] Radboud Univ Nijmegen Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[2] Nijmegen Inst Infect Inflammat & Immun N4i, Nijmegen, Netherlands

[3] Univ Colorado Denver, Dept Med, Aurora, CO USA

来源：

SEMINARS IN IMMUNOLOGY | 2013年 / 25卷 / 06期

关键词：

Interleukin-36; Pathogenesis; IL-1; family; Skin inflammation; GENERALIZED PUSTULAR PSORIASIS; NF-KAPPA-B; INTERLEUKIN-36-RECEPTOR ANTAGONIST DEFICIENCY; BRONCHIAL EPITHELIAL-CELLS; GENE-EXPRESSION PROFILE; RECEPTOR ANTAGONIST; FAMILY-MEMBER; MURINE MODEL; IN-VITRO; T-CELLS;

D O I：

10.1016/j.smim.2013.11.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-36 alpha, IL-36 beta, IL-36 gamma, and IL-36Ra, collectively called IL-36 cytokines, are part of the IL-1 family. IL-36 alpha, IL-36 beta, and IL-36 gamma are IL-36 receptor (IL-36R) agonists, while IL-36Ra is a receptor antagonist that blocks the activation of IL-36R signaling. IL-36 cytokines require processing in order to become fully active, however the protease(s) responsible for this are currently not known. The IL-36 receptor pathway activates dendritic cells and plays a role in polarizing T-helper responses. The skin is the predominant site where IL-36 cytokines are expressed and several reports have established that they play a significant role in the pathogenesis of skin diseases. In this review the discovery and biological function of the cytokines IL-36 alpha, IL-36 beta, IL-36 gamma and IL-36Ra will be discussed, and their role in the pathogenesis of a wide variety of diseases. (C) 2013 Elsevier Ltd. All rights reserved

引用

页码：458 / 465

页数：8

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