Chirality of the cytoskeleton in the origins of cellular asymmetry

被引:21
作者
Satir, Peter [1 ]
机构
[1] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA
关键词
bacterial flagellum; actin filament; microtubules; basal body; cilia; asymmetry; LISTERIA-MONOCYTOGENES; STRUCTURAL BASIS; ACTIN-FILAMENTS; SURFACE LATTICE; MICROTUBULES; POLARITY; CILIUM; PROTOFILAMENT; CONTRACTION; MECHANISMS;
D O I
10.1098/rstb.2015.0408
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Self-assembly of two important components of the cytoskeleton of eukaryotic cells, actin microfilaments and microtubules (MTs) results in polar filaments of one chirality. As is true for bacterial flagella, in actin microfilaments, screw direction is important for assembly processes and motility. For MTs, polar orientation within the cell is paramount. The alignment of these elements in the cell cytoplasm gives rise to emergent properties, including the potential for cell differentiation and specialization. Complex MTs with a characteristic chirality are found in basal bodies and centrioles; this chirality is preserved in cilia. In motile cilia, it is reflected in the direction of the effective stroke. The positioning of the basal body or cilia on the cell surface depends on polarity proteins. In evolution, survival depends on global polarity information relayed to the cell in part by orientation of the MT and actin filament cytoskeletons and the chirality of the basal body to determine left and right coordinates within a defined anterior-posterior cell and tissue axis. This article is part of the themed issue 'Provocative questions in left-right asymmetry'.
引用
收藏
页数:7
相关论文
共 45 条
[41]   Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography [J].
Lacomble, Sylvain ;
Vaughan, Sue ;
Gadelha, Catarina ;
Morphew, Mary K. ;
Shaw, Michael K. ;
McIntosh, J. Richard ;
Gull, Keith .
JOURNAL OF CELL SCIENCE, 2009, 122 (08) :1081-1090
[42]   Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation [J].
Asai, Rieko ;
Sinha, Shubham ;
Prakash, Vivek N. ;
Mikawa, Takashi .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 122 (06)
[43]   NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division [J].
Liu, Ji ;
Maduzia, Lisa L. ;
Shirayama, Masaki ;
Mello, Craig C. .
DEVELOPMENTAL BIOLOGY, 2010, 339 (02) :366-373
[44]   The role of asymmetry of nervous and immune systems in the formation of cellular immunity of (CBaxC57Bl/6) F1 mice [J].
Gontova, IA ;
Abramov, VV ;
Kozlov, VA .
NEUROIMMUNOMODULATION, 2004, 11 (06) :385-391
[45]   HRS 40th anniversary viewpoints: Present at the creation-My viewpoint on the origins of cellular and clinical electrophysiology of arrhythmias [J].
Wit, Andrew L. .
HEART RHYTHM, 2019, 16 (08) :1294-1295