Wnt/β-catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer

被引：45
作者：
Zhu, Gui-Xian [1 ,2 ]
Gao, Dian [3 ]
Shao, Zhao-Zhao [1 ]
Chen, Li [1 ]
Ding, Wen-Jie [1 ]
Yu, Qiong-Fang [1 ]
机构：
[1] Nanchang Univ, Dept Gastroenterol & Hepatol, Affiliated Hosp 2, 1 Minde Rd, Nanchang 330006, Jiangxi, Peoples R China
[2] Nanchang Univ, Clin Med Coll 2, Nanchang 330006, Jiangxi, Peoples R China
[3] Nanchang Univ, Dept Pathogen Biol & Immunol, Coll Med, Nanchang 330006, Jiangxi, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2021年 / 23卷 / 02期
关键词：
colorectal cancer; Wnt/beta-catenin signaling; drug resistance; tumor stem cells; non-coding RNAs; tumor microenvironment; EPITHELIAL-MESENCHYMAL TRANSITION; STEM-CELL NICHE; COLON-CANCER; BETA-CATENIN; GENE-EXPRESSION; NONCODING RNAS; GASTRIC-CANCER; TUMOR MICROENVIRONMENT; MULTIDRUG-RESISTANCE; DOWN-REGULATION;
D O I：
10.3892/mmr.2020.11744
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer (CRC) is the third most common malignant tumor in humans. Chemotherapy is used for the treatment of CRC. However, the effect of chemotherapy remains unsatisfactory due to drug resistance. Growing evidence has shown that the presence of highly metastatic tumor stem cells, regulation of non-coding RNAs and the tumor microenvironment contributes to drug resistance mechanisms in CRC. Wnt/beta-catenin signaling mediates the chemoresistance of CRC in these three aspects. Therefore, the present study analyzed the abundant evidence of the contribution of Wnt/beta-catenin signaling to the development of drug resistance in CRC and discussed its possible role in improving the chemosensitivity of CRC, which may provide guidelines for its clinical treatment.
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页数：13
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