Molecular motors and the Golgi complex: Staying put and moving through

被引：50
作者：
Brownhill, Kim [1 ]
Wood, Laura [1 ]
Allan, Viki [1 ]
机构：
[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2009年 / 20卷 / 07期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
Golgi; Actin; Microtubule; Kinesin; Dynein; Myosin; Secretion; Cell migration; MICROTUBULE-ORGANIZING CENTER; KINESIN-LIKE PROTEIN; CYTOPLASMIC DYNEIN; ENDOPLASMIC-RETICULUM; VESICLE TRANSPORT; INTERMEDIATE COMPARTMENT; MEMBRANE TRAFFICKING; AXONAL-TRANSPORT; LEADING-EDGE; MYOSIN-VI;
D O I：
10.1016/j.semcdb.2009.03.019
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Golgi apparatus is a highly dynamic organelle through which nascent proteins released from the endoplasmic reticulum (ER) are trafficked. Proteins are post-translationally modified within the Golgi and subsequently packaged into carriers for transport to a variety of cellular destinations. This transit of proteins, as well as the maintenance of Golgi structure and position, is highly dependent upon the actin and microtubule cytoskeletons and their associated molecular motors. Here we review how motors contribute to the correct functioning of the Golgi in higher eukaryotes and discuss the secretory pathway as a model system for studying cooperation between motor proteins. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：784 / 792
页数：9
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