Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14

被引：146

作者：

Gardner, MJ

Shallom, SJ

Carlton, JM

Salzberg, SL

Nene, V

Shoaibi, A

Ciecko, A

Lynn, J

Rizzo, M

Weaver, B

Jarrahi, B

Brenner, M

Parvizi, B

Tallon, L

Moazzez, A

Granger, D

Fujii, C

Hansen, C

Pederson, J

Feldblyum, T

Peterson, J

Suh, B

Angiuoli, S

Pertea, M

Allen, J

Selengut, J

White, O

Cummings, LM

Smith, HO

Adams, MD

Venter, JC

Carucci, DJ

Hoffman, SL

Fraser, CM

机构：

[1] Inst Genom Res, Rockville, MD 20850 USA

[2] USN, Malaria Program, Med Res Ctr, Silver Spring, MD 20910 USA

来源：

NATURE | 2002年 / 419卷 / 6906期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nature01094

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mosquito-borne malaria parasite Plasmodium falciparum kills an estimated 0.7-2.7 million people every year, primarily children in sub-Saharan Africa. Without effective interventions, a variety of factors-including the spread of parasites resistant to antimalarial drugs and the increasing insecticide resistance of mosquitoes-may cause the number of malaria cases to double over the next two decades(1). To stimulate basic research and facilitate the development of new drugs and vaccines, the genome of Plasmodium falciparum clone 3D7 has been sequenced using a chromosome- by-chromosome shotgun strategy(2-4). We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence(5). These chromosomes represent about 35% of the 23-megabase P. falciparum genome.

引用

页码：531 / 534

页数：4

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