Ante mortem diagnosis of amoebic encephalitis in a haematopoietic stem cell transplanted patient

被引:8
作者
Abd, Hadi [1 ]
Saeed, Amir [1 ,2 ]
Jalal, Sha [2 ]
Bekassy, Albert N. [3 ]
Sandstrom, Gunnar [1 ,2 ]
机构
[1] Swedish Inst Infect Dis Control, Ctr Microbiol Preparedness, SE-17182 Solna, Sweden
[2] Karolinska Univ Hosp, Karolinska Inst, Dept Lab Med, Div Clin Microbiol, Stockholm, Sweden
[3] Univ Lund Hosp, Blood & Marrow Transplant Team, Lund, Sweden
关键词
FREE-LIVING AMEBAS; ACANTHAMOEBA-MENINGOENCEPHALITIS; BALAMUTHIA-MANDRILLARIS; SAPPINIA-DIPLOIDEA; NAEGLERIA-FOWLERI; INDIA;
D O I
10.1080/00365540903015117
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Acanthamoeba species are widely distributed free-living amoebae showing an increased role as human pathogens causing encephalitis, keratitis, pneumonitis and dermatitis. A haematopoietic stem cell transplanted (HSCT) patient developed purulent meningitis while awaiting regrafting. The meningitis was thought to be an endogenous infection arising from the mucous membranes primarily involving the cervicofacial regions, probably due to haematogenous spread facilitated by surgery. We diagnosed a fatal case of granulomatous amoebic encephalitis caused by Acanthamoeba castellanii by direct microscopy of a cerebrospinal fluid sample (CSF), Acanthamoeba cultivation, Giemsa staining, polymerase chain reaction and sequencing.
引用
收藏
页码:619 / 622
页数:4
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