Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines

被引：152

作者：

Devarbhavi, Harshad ^{[1
]}

Aithal, Guruprasad ^{[2
,3
]}

Treeprasertsuk, Sombat ^{[4
]}

Takikawa, Hajime ^{[5
]}

Mao, Yimin ^{[6
,7
]}

Shasthry, Saggere M. ^{[8
]}

Hamid, Saeed ^{[9
]}

Tan, Soek Siam ^{[10
]}

Philips, Cyriac Abby ^{[11
]}

George, Jacob ^{[12
,13
]}

Jafri, Wasim ^{[9
]}

Sarin, Shiv K. ^{[8
]}

机构：

[1] St Johns Med Coll Hosp, Dept Gastroenterol & Hepatol, Bangalore, Karnataka, India

[2] Nottingham Univ Hosp NHS Trust, NIHR Nottingham Biomed Res Ctr, Nottingham, England

[3] Univ Nottingham, Nottingham, England

[4] Chulalongkorn Univ, Dept Med, Bangkok, Thailand

[5] Fac Med Technol, Sch Med, Tokyo, Japan

[6] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Div Gastroenterol & Hepatol,Shanghai Inst Digest, Shanghai, Peoples R China

[7] Shanghai Jiao Tong Univ, Sch Med, Clin Res Ctr, Shanghai, Peoples R China

[8] Inst Liver & Biliary Sci, Dept Hepatol, New Delhi, India

[9] Aga Khan Univ Hosp, Dept Med, Karachi, Pakistan

[10] Hosp Selayang, Dept Med, Bata Caves, Selangor, Malaysia

[11] Rajagiri Hosp, Ctr Excellence GI Sci, Liver Inst, Aluva, Kerala, India

[12] Westmead Hosp, Dept Gastroenterol & Hepatol, Sydney, NSW, Australia

[13] Sydney West Local Hlth Dist, Sydney, NSW, Australia

来源：

HEPATOLOGY INTERNATIONAL | 2021年 / 15卷 / 02期

关键词：

APASL; DILI; Consensus; Guidelines; Hepatotoxicity; Drug-induced liver injury; Medications; Risk factors; Tuberculosis; Antituberculosis drugs; Monitoring; Treatment; Traditional and complimentary medicine; INTRAVENOUS N-ACETYLCYSTEINE; SINGLE-CENTER EXPERIENCE; TERM-FOLLOW-UP; CAUSALITY ASSESSMENT; AUTOIMMUNE HEPATITIS; CLINICAL-FEATURES; RISK-FACTORS; NONALCOHOLIC STEATOHEPATITIS; SEVERE HEPATOTOXICITY; ADVERSE REACTIONS;

D O I：

10.1007/s12072-021-10144-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Idiosyncratic drug-induced liver injury mimics acute and chronic liver disease. It is under recognized and underrecognised because of the lack of pathognomonic diagnostic serological markers. Its consequences may vary from being asymptomatic to self-limiting illness to severe liver injury leading to acute liver failure. Its incidence is likely to be more common in Asia than other parts of the world, mainly because of hepatotoxicity resulting from the treatment of tuberculosis disease and the ubiquitous use of traditional and complimentary medicines in Asian countries. This APASL consensus guidelines on DILI is a concise account of the various aspects including current evidence-based information on DILI with special emphasis on DILI due to antituberculosis agents and traditional and complementary medicine use in Asia.

引用

页码：258 / 282

页数：25

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