Latest on biomaterial-based therapies for topical treatment of psoriasis

被引:14
作者
Chen, Anqi [1 ,2 ]
Luo, Yuting [2 ]
Xu, Jie [2 ]
Guan, Xueran [2 ]
He, Huacheng [3 ]
Xuan, Xuan [1 ]
Wu, Jiang [1 ,2 ]
机构
[1] Wenzhou Med Univ, Dept Dermatol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Key Lab Biotechnol & Pharmaceut Engn, Wenzhou 325035, Peoples R China
[3] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China
基金
中国国家自然科学基金;
关键词
SOLID LIPID NANOPARTICLES; IMIQUIMOD-INDUCED PSORIASIS; TRANSDERMAL DRUG-DELIVERY; BOX-BEHNKEN DESIGN; IN-VITRO; DISSOLVING MICRONEEDLE; ELECTROSPUN NANOFIBERS; TISSUE REGENERATION; PLGA NANOPARTICLES; ENHANCED DELIVERY;
D O I
10.1039/d2tb00614f
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Psoriasis is an autoimmune inflammatory disease which is fundamentally different from dermatitis. Its treatments include topical medications and systemic drugs depending on different stages of the disease. However, these commonly used therapies are falling far short of clinical needs due to various drawbacks. More precise therapeutic strategies with minimized side effects and improved compliance are highly demanded. Recently, the rapid development of biomaterial-based therapies has made it possible and promising to attain topical psoriasis treatment. In this review, we briefly describe the significance and challenges of the topical treatment of psoriasis and emphatically overview the latest progress in novel biomaterial-based topical therapies for psoriasis including microneedles, nanoparticles, nanofibers, and hydrogels. Current clinical trials related to each biomaterial are also summarized and discussed.
引用
收藏
页码:7397 / 7417
页数:21
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