Pathogenesis of dengue virus diseases: missing pieces in the jigsaw

被引：43
作者：
BielefeldtOhmann, H
机构：
[1] Centre for Molecular Biotechnology (Arbovirology Group), School of Life Science, Queensland University of Technology, Brisbane, QLD 4001
来源：
TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 10期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0966-842X(97)01126-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanisms involved in the pathogenesis of dengue hemorrhagic fever and dengue shock syndrome remain unresolved. Antibody-dependent enhancement of infection has long been thought to play a central role; however, this remains unverified. The alternative hypothesis that virus variation, virulence and dynamics may account for severe dengue disease, particularly in children, should be considered.
引用
收藏
页码：409 / 413
页数：5
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