Viral load of human papillomavirus and risk of CIN3 or cervical cancer

被引：226

作者：

Lorincz, AT

Castle, PE

Sherman, ME

Scott, DR

Glass, AG

Wacholder, S

Rush, BB

Gravitt, PE

Schussler, JE

Schiffman, M

机构：

[1] Digene Corp, Gaithersburg, MD 20878 USA

[2] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[3] Kaiser Permanente, Portland, OR USA

[4] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[5] Informat Management Serv Inc, Silver Spring, MD USA

来源：

LANCET | 2002年 / 360卷 / 9328期

关键词：

D O I：

10.1016/S0140-6736(02)09463-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Carcinogenic human papillomaviruses (HPV) are thought to be necessary for development of cervical cancer. We assessed whether higher viral loads of such viruses predicted future risk of CIN3 or cancer (CIN3+) in a cohort of 20 810 women followed up for 10 years with cytological screening. We measured the viral load for 13 types of carcinogenic HPV (relative light units normalised to 1 pg/mL HPV 16 positive controls [RLU/PC]) using Hybrid Capture 2 testing of cervicovaginal lavages obtained at enrolment. Results were stratified into four groups (RLU/PC 1 to <10, 10 to <100, 100 to <1000, ≥1000). Although presence of HPV strongly Increased risk of CIN3+, high viral load did not further predict risk of CIN3+.

引用

页码：228 / 229

页数：2

共 5 条

[1]

OSTOR AG, 1993, INT J GYNECOL PATHOL, V12, P186

[2] HPV DNA testing in cervical cancer screening - Results from women in a high-risk province of Costa Rica [J].

Schiffman, M ;

Herrero, R ;

Hildesheim, A ;

Sherman, ME ;

Bratti, M ;

Wacholder, S ;

Alfaro, M ;

Hutchinson, M ;

Morales, J ;

Greenberg, MD ;

Lorincz, AT .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (01) :87-93

[3] EPIDEMIOLOGIC EVIDENCE SHOWING THAT HUMAN PAPILLOMAVIRUS INFECTION CAUSES MOST CERVICAL INTRAEPITHELIAL NEOPLASIA [J].

SCHIFFMAN, MH ;

BAUER, HM ;

HOOVER, RN ;

GLASS, AG ;

CADELL, DM ;

RUSH, BB ;

SCOTT, DR ;

SHERMAN, ME ;

KURMAN, RJ ;

WACHOLDER, S ;

STANTON, CK ;

MANOS, MM .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (12) :958-964

[4] Use of human papillomavirus DNA testing to compare equivocal cervical cytologic interpretations in the United States, Scandinavia, and the United Kingdom [J].

Scott, DR ;

Hagmar, B ;

Maddox, P ;

Hjerpe, A ;

Dillner, J ;

Cuzick, J ;

Sherman, ME ;

Stoler, MH ;

Kurman, RJ ;

Kiviat, NB ;

Manos, MM ;

Schiffman, M .

CANCER CYTOPATHOLOGY, 2002, 96 (01) :14-20

[5] Consistent high viral load of human papillomavirus 16 and risk of cervical carcinoma in situ:: a nested case-control study [J].

Ylitalo, N ;

Sorensen, P ;

Josefsson, AM ;

Magnusson, PKE ;

Andersen, PK ;

Pontén, J ;

Adami, HO ;

Gyllensten, UB ;

Melbye, M .

LANCET, 2000, 355 (9222) :2194-2198

← 1 →